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dentification of dried squid merchandise purchased in China using DNA barcoding
Omar- posted on
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Molecular identification of dried squid merchandise bought in China utilizing DNA barcoding and SYBR inexperienced exact time PCR.
Dried squid merchandise are commonplace in China as a snack meals, side dishes, or refreshments, and the market attraction is also mirrored by the excessive worth that usually reaches 497 RMB per kg.
Nonetheless, the absence of harmonisation all through the definition of squid, together with the issues with seen inspection for processed seafood merchandise, make quite a few species substitution for dried squid merchandise a frequent prevalence.
The goal of the current evaluation was to utilize a DNA barcoding method for species identification of 48 dried squid merchandise collected from essential on-line searching for platform in China.
Furthermore, we furthermore developed a novel SYBR inexperienced real-time PCR assay (simplex and duplex adopted by a melting curve evaluation) particular for Illex argentinus and Todarodes pacificus based completely on cytochrome C oxidase subunit I (COI) gene.
Outcomes highlighted the worthwhile DNA extraction and PCR amplification of a 655 bp COI gene fragment from all merchandise.
A most similarity worth all through the vary of 98-100% was obtained for all readable sequences utilizing the BOLD and BLAST public databases and 4 species (Dosidicus gigas, Uroteuthis edulis, I. argentinus, and T. pacificus) have been acknowledged.
The specificity of the designed primer fashions was confirmed in route of 23 non-target species, and the newly developed strategies have been successfully utilized to present I. argentinus and T. pacificus in dried squid merchandise.
Full, DNA barcoding is a sturdy software program program for seafood species identification and the novel methodology is atmosphere pleasant in screening I. argentinus and T. pacificus in meals merchandise.
Mouse Podoplanin (PDPN) ELISA Kit |
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| DLR-PDPN-Mu-48T | DL Develop | 48T | EUR 632.4 |
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids. |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| DLR-PDPN-Mu-96T | DL Develop | 96T | EUR 825.6 |
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Description: A sandwich quantitative ELISA assay kit for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates or other biological fluids. |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| abx571749-96tests | Abbexa | 96 tests | EUR 943.2 |
Mouse Podoplanin, Pdpn ELISA KIT |
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| ELI-06723m | Lifescience Market | 96 Tests | EUR 1038 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| SEC719Mu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5834.88 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids. |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| SEC719Mu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 585.7 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids. |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| SEC719Mu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 785.28 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids. |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| SEC719Mu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 3173.76 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Podoplanin (PDPN) in tissue homogenates, cell lysates and other biological fluids. |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| 4-SEC719Mu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Podoplanin (PDPN) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
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Mouse Podoplanin (PDPN) ELISA Kit |
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| RD-PDPN-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 639.6 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| RD-PDPN-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 888 |
Mouse Podoplanin(PDPN)ELISA kit |
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| QY-E21215 | Qayee Biotechnology | 96T | EUR 433.2 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| RDR-PDPN-Mu-48Tests | Reddot Biotech | 48 Tests | EUR 668.4 |
Mouse Podoplanin (PDPN) ELISA Kit |
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| RDR-PDPN-Mu-96Tests | Reddot Biotech | 96 Tests | EUR 928.8 |
Mouse Podoplanin (PDPN)ELISA kit |
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| YLA0596MO-48T | Shanghai YL Biotech | 48T | EUR 465 |
Mouse Podoplanin (PDPN)ELISA kit |
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| YLA0596MO-96T | Shanghai YL Biotech | 96T | EUR 600 |
Podoplanin |
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| MO47016 | Neuromics | 100 ul | EUR 418.8 |
ELISA kit for Mouse Podoplanin (PDPN) |
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| KTE70775-48T | Abbkine | 48T | EUR 398.4 |
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Description: Quantitative sandwich ELISA for measuring Mouse Podoplanin (PDPN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Mouse Podoplanin (PDPN) |
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| KTE70775-5platesof96wells | Abbkine | 5 plates of 96 wells | EUR 2538 |
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Description: Quantitative sandwich ELISA for measuring Mouse Podoplanin (PDPN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Mouse Podoplanin (PDPN) |
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| KTE70775-96T | Abbkine | 96T | EUR 646.8 |
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Description: Quantitative sandwich ELISA for measuring Mouse Podoplanin (PDPN) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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Recombinant Mouse Podoplanin (C-Fc) |
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| CU73-1mg | Novoprotein | 1mg | EUR 2008.8 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse Podoplanin (C-Fc) |
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| CU73-500ug | Novoprotein | 500ug | EUR 1399.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse Podoplanin (C-Fc) |
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| CU73-50ug | Novoprotein | 50ug | EUR 327.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse Podoplanin (C-Fc) |
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| CU73-10ug | Novoprotein | 10ug | EUR 157.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Podoplanin (PDPN) Polyclonal Antibody (Mouse) |
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| 4-PAC719Mu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN) |
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ELISA kit for Mouse PDPN (Podoplanin) |
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| ELK7080 | ELK Biotech | 1 plate of 96 wells | EUR 518.4 |
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Description: A sandwich ELISA kit for detection of Podoplanin from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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ELISA kit for Mouse PDPN (Podoplanin) |
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| E-EL-M2409 | Elabscience Biotech | 1 plate of 96 wells | EUR 640.8 |
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Description: A sandwich ELISA kit for quantitative measurement of Mouse PDPN (Podoplanin) in samples from Serum, Plasma, Cell supernatant |
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Podoplanin antibody |
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| 70R-11540 | Fitzgerald | 100 ug | EUR 632.4 |
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Description: Rabbit polyclonal Podoplanin antibody |
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Podoplanin Antibody |
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| 49474-100ul | SAB | 100ul | EUR 399.6 |
Podoplanin Antibody |
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| 49474-50ul | SAB | 50ul | EUR 286.8 |
Podoplanin antibody |
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| 10R-P133a | Fitzgerald | 100 ug | EUR 608.4 |
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Description: Mouse monoclonal Podoplanin antibody |
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Podoplanin antibody |
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| 10R-P155a | Fitzgerald | 100 ug | EUR 651.6 |
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Description: Hamster monoclonal Podoplanin antibody |
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Podoplanin antibody |
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| 10R-7662 | Fitzgerald | 100 ug | EUR 754.8 |
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Description: Mouse monoclonal Podoplanin antibody |
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Podoplanin antibody |
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| 10R-7663 | Fitzgerald | 100 ug | EUR 754.8 |
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Description: Hamster monoclonal Podoplanin antibody |
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Podoplanin antibody |
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| 10R-7664 | Fitzgerald | 100 ug | EUR 754.8 |
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Description: Mouse monoclonal Podoplanin antibody |
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Podoplanin antibody |
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| 70R-50819 | Fitzgerald | 100 ul | EUR 292.8 |
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Description: Purified Polyclonal Podoplanin antibody |
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Podoplanin antibody |
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| 70R-PR007 | Fitzgerald | 100 ug | EUR 506.4 |
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Description: Affinity purified Rabbit polyclonal Podoplanin antibody |
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Podoplanin antibody |
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| 70R-13952 | Fitzgerald | 100 ug | EUR 366 |
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Description: Affinity purified Rabbit polyclonal Podoplanin antibody |
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Podoplanin antibody |
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| 70R-6816 | Fitzgerald | 50 ug | EUR 560.4 |
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Description: Rabbit polyclonal Podoplanin antibody raised against the N terminal of PDPN |
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Podoplanin antibody |
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| 70R-6817 | Fitzgerald | 50 ug | EUR 560.4 |
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Description: Rabbit polyclonal Podoplanin antibody raised against the middle region of PDPN |
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Podoplanin Antibody |
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| DF12456 | Affbiotech | 200ul | EUR 420 |
Podoplanin Antibody |
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| P1051-01m | SAB | 0.1m | EUR 250.8 |
Podoplanin Antibody |
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| P1051-1ml | SAB | 1ml | EUR 1129.2 |
Podoplanin Antibody |
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| R33852-100UG | NSJ Bioreagents | 100 ug | EUR 339.15 |
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Description: Additional name(s) for this target protein: PDPN; AGGRUS; GP36; GP40; Gp38; HT1A-1; OTS8; PA2.26 |
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Podoplanin (PDPN) Polyclonal Antibody (Mouse), PE |
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| 4-PAC719Mu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with PE. |
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Podoplanin (PDPN) Polyclonal Antibody (Mouse), APC |
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| 4-PAC719Mu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with APC. |
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Podoplanin (PDPN) Polyclonal Antibody (Mouse), Cy3 |
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| 4-PAC719Mu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with Cy3. |
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Podoplanin (PDPN) Polyclonal Antibody (Mouse), HRP |
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| 4-PAC719Mu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with HRP. |
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Anti-D2-40 Podoplanin antibody |
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| STJ16100360 | St John's Laboratory | 1 mL | EUR 1482 |
Anti-D2-40/Podoplanin antibody |
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| STJ190048 | St John's Laboratory | 200 µl | EUR 236.4 |
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Description: Unconjugated Mouse monoclonal to D2-40/Podoplanin (7D1) |
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Podoplanin (PDPN) Polyclonal Antibody (Mouse), FITC |
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| 4-PAC719Mu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with FITC. |
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Podoplanin (PDPN) Antibody |
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| 20-abx114559 | Abbexa |
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Podoplanin (PDPN) Antibody |
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| 20-abx005408 | Abbexa |
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Podoplanin (PDPN) Antibody |
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| 20-abx008317 | Abbexa |
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Podoplanin (PDPN) Antibody |
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| 20-abx174125 | Abbexa |
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Podoplanin (PDPN) Antibody |
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| 20-abx174126 | Abbexa |
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Podoplanin (PDPN) Antibody |
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| 20-abx178065 | Abbexa |
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Podoplanin (PDPN) Antibody |
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| 20-abx178066 | Abbexa |
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Podoplanin (PDPN) Antibody |
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| 20-abx178067 | Abbexa |
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Podoplanin (PDPN) Antibody |
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| 20-abx211099 | Abbexa |
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Podoplanin (PDPN) Antibody |
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| abx236598-100ug | Abbexa | 100 ug | EUR 661.2 |
Podoplanin (PDPN) Antibody |
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| abx236599-100ug | Abbexa | 100 ug | EUR 661.2 |
Podoplanin (PDPN) Antibody |
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| 20-abx123399 | Abbexa |
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Podoplanin (PDPN) Antibody |
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| 20-abx137407 | Abbexa |
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Podoplanin (PDPN) Antibody |
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| 20-abx129101 | Abbexa |
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Podoplanin (PDPN) Antibody |
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| 20-abx131102 | Abbexa |
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Podoplanin (PDPN) Antibody |
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| abx433110-200ul | Abbexa | 200 ul | EUR 460.8 |
Podoplanin (PDPN) Antibody |
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| 20-abx339428 | Abbexa |
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Pdpn Antibody /Podoplanin |
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| RQ6390 | NSJ Bioreagents | 100 ug | EUR 356.15 |
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Description: Podoplanin (PDPN) is a protein that in humans is encoded by the PDPN gene. This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The International radiation Hybrid mapping consortium mapped the T1A gene to chromosome 1. It has got 162 amino acid protein which is a typical type I membrane glycoprotein, with an N-terminal signal sequence, a signal sequence cleavage site, a C-terminal hydrophobic stretch, and a short cytoplasmic tail. Northern blot analysis detected a 1.2-kb T1A2 transcript only in lung. It has been described as a differentiation antigen and influenza-virus receptor, and a marker of lung injury. |
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Podoplanin Antibody gp36 |
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| R30481 | NSJ Bioreagents | 100 ug | EUR 356.15 |
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Description: Podoplanin is a protein that in humans is encoded by the PDPN gene. This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The International radiation Hybrid mapping consortium mapped the gene to chromosome 1. It is a typical type I membrane glycoprotein, with an N-terminal signal sequence, a signal sequence cleavage site, a C-terminal hydrophobic stretch, and a short cytoplasmic tail. It has been described as a differentiation antigen and influenza-virus receptor, and a marker of lung injury. |
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Podoplanin Antibody / gp36 |
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| R30760 | NSJ Bioreagents | 100 ug | EUR 356.15 |
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Description: PDPN (Podoplanin), also called T1A, T1A2, GP36, OTS8 or AGGRUS, is a protein that in humans is encoded by the PDPN gene. This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The PDPN gene is mapped to chromosome 1 by the International radiation Hybrid mapping consortium. The physiological function of PDPN may be related to its mucin-type character. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Immunohistochemical analysis of PDPN in placenta, kidney, lung, and nasal polyps showed expression at the apical plasma membrane of vascular endothelial cells and in alveolar epithelial cells. Overexpression of rat PDPN in human and rodent endothelial cells promoted formation of elongated cell extensions and significantly increased endothelial cell adhesion, migration, and tube formation. Inhibition of PDPN expression by small interfering RNAs decreased cell adhesion in cultured human dermal lymphatic endothelial cells. |
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Podoplanin Antibody / gp36 |
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| V3404-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
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Description: Podoplanin (PDPN) is a muco-protein which localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endothelium as well as lymphoangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas. |
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Podoplanin Antibody / gp36 |
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| V3404-20UG | NSJ Bioreagents | 20 ug | EUR 153.3 |
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Description: Podoplanin (PDPN) is a muco-protein which localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endothelium as well as lymphoangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas. |
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Podoplanin Antibody / gp36 |
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| V3404SAF-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
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Description: Podoplanin (PDPN) is a muco-protein which localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endothelium as well as lymphoangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas. |
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Podoplanin Antibody / gp36 |
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| V8695-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
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Description: It recognizes a muco-protein of 38-43kDa, which is identified as Podoplanin (PDPN). It localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endotheliumas well as lymphoangiomas,Kaposi sarcomas,and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas. |
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Podoplanin Antibody / gp36 |
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| V8695-20UG | NSJ Bioreagents | 20 ug | EUR 153.3 |
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Description: It recognizes a muco-protein of 38-43kDa, which is identified as Podoplanin (PDPN). It localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endotheliumas well as lymphoangiomas,Kaposi sarcomas,and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas. |
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Podoplanin Antibody / gp36 |
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| V8695SAF-100UG | NSJ Bioreagents | 100 ug | EUR 349.3 |
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Description: It recognizes a muco-protein of 38-43kDa, which is identified as Podoplanin (PDPN). It localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endotheliumas well as lymphoangiomas,Kaposi sarcomas,and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas. |
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Mouse Anti-Human Podoplanin monoclonal antibody, clone JID761 |
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| CABT-L2919-100uL500uL | Creative Diagnostics | 100 uL, 500 uL | EUR 602.4 |
Podoplanin (PDPN) Polyclonal Antibody (Mouse), APC-Cy7 |
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| 4-PAC719Mu01-APC-Cy7 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with APC-Cy7. |
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Podoplanin (PDPN) Antibody (Cy3) |
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| 20-abx274445 | Abbexa |
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Podoplanin (PDPN) Polyclonal Antibody (Mouse), Biotinylated |
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| 4-PAC719Mu01-Biotin | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Mouse Podoplanin (PDPN). This antibody is labeled with Biotin. |
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Podoplanin Conjugated Antibody |
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| C49474 | SAB | 100ul | EUR 476.4 |
Podoplanin (PDPN) Protein |
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| 20-abx262003 | Abbexa |
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Pig Podoplanin ELISA kit |
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| E07P0082-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A sandwich ELISA for quantitative measurement of Porcine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Podoplanin ELISA kit |
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| E07P0082-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A sandwich ELISA for quantitative measurement of Porcine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig Podoplanin ELISA kit |
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| E07P0082-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A sandwich ELISA for quantitative measurement of Porcine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog Podoplanin ELISA kit |
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| E08P0082-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A sandwich ELISA for quantitative measurement of Canine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog Podoplanin ELISA kit |
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| E08P0082-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A sandwich ELISA for quantitative measurement of Canine Podoplanin in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Molecular Insights Into Therapeutic Potential of Autophagy Modulation by Pure Merchandise for Most cancers Stem Cells.
Autophagy, a cell self-digestion course of that’s activated in response to emphasize, has a wise place in tumor formation and enchancment.
Most cancers stem cells (CSCs) accounting for a minor proportion of full most cancers cells-have distinct self-renewal and differentiation experience and promote metastasis.
Researchers have confirmed {{{that a}}} numeral variety of pure merchandise utilizing commonplace experimental strategies have been revealed to give consideration to CSCs.
Nonetheless, the precise place of autophagy with respect to CSCs and tumorigenesis utilizing pure merchandise are nonetheless unknown.
In the mean time, CSCs are thought-about to be one amongst many causative causes underlying the failure of anticancer remedy on account of tumor recurrence, metastasis, and chemo- or radio-resistance.
Autophagy might play a twin place in CSC-related resistance to anticancer remedy; it’s liable for cell future dedication and the focused degradation of transcription components by means of progress arrest.
It has been established that autophagy promotes drug resistance, dormancy, and stemness and upkeep of CSCs.
Surprisingly, pretty only a few evaluation have furthermore urged that autophagy can facilitate the scarcity of stemness in CSCs. Correct proper right here, we analysis present progress in analysis associated to the multifaceted connections between autophagy modulation and CSCs administration utilizing pure merchandise.
Full, we emphasize the significance of understanding the place of autophagy all through the upkeep of assorted CSCs and implications of this connection for the event of newest methods for a lot of cancers remedy concentrating on pure merchandise.
Probing the Molecular-Stage Interactions in an Vigorous Pharmaceutical Ingredient (API) – Polymer Dispersion and the Ensuing Affect on Drug Product Formulation.
An investigation of underlying mechanisms of API-polymer interplay patterns has the potential to offer invaluable insights for choosing acceptable formulations with superior bodily stability and processability.In this evaluation, copovidone was used as a polymeric provider for a variety of mannequin compounds together with clotrimazole, nifedipine, and posaconazole.
The diversified chemical constructions conferred the flexibleness for the mannequin compounds to sort distinct interactions with copovidone. Rheology and nuclear magnetic resonance (NMR) have been mixed to research the molecular sample and relative energy of energetic pharmaceutical ingredient (API)-polymer interactions.
Along with, the have an effect on of the interactions on formulation processability by means of scorching soften extrusion (HME) and bodily stability have been evaluated.The rheological response of an API-polymer system was discovered to be terribly delicate to API-polymer interplay, relying each on API chemistry and API-polymer miscibility.
Contained in the strategies studied, dispersed API induced a stronger plasticizer have an effect on on the polymer matrix in contrast with crystalline/aggregated API. Correspondingly, the processing torque by means of HME confirmed a proportional relationship with the utmost tough viscosity of the API-polymer system.
As a methodology to quantitatively keep in mind the relative energy of the API-polymer interplay, homogeneously dispersed API-polymer amorphous samples have been ready by HME at an elevated temperature.
DSC, XRD, and rheology have been employed to verify the amorphous integrity and homogeneity of the resultant extrudates.
Subsequently, the homogeneously dispersed API-polymer amorphous dispersions have been interrogated by rheology and NMR to offer a qualitative and quantitative evaluation of the character of the API-polymer interplay, each macroscopically and microscopically.
Rheological grasp curves of frequency sweeps of the extrudates exhibited a sturdy dependence on the API chemistry and revealed a rank ordering of the relative energy of API-copovidone interactions, all through the order of posaconazole > nifedipine > clotrimazole.
NMR knowledge offered the means to exactly map the API-polymer interplay sample and arrange the precise web pages of interplay from a molecular perspective.
Lastly, the have an effect on of API-polymer interactions on the bodily stability of the resultant extrudates was studied.Qualitative and quantitative analysis of the relative energy of the API-polymer interplay was successfully achieved by using mixed rheology and NMR. Graphical Summary.
GRO / KC (CXCL1) Protein |
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| 20-abx260684 | Abbexa |
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GRO / KC (CXCL1) Protein |
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| 20-abx261870 | Abbexa |
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Mouse CXC-chemokine ligand 1(CXCL1/KC)ELISA Kit |
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| YLA0122MO-48T | Shanghai YL Biotech | 48T | EUR 465 |
Mouse CXC-chemokine ligand 1(CXCL1/KC)ELISA Kit |
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| YLA0122MO-96T | Shanghai YL Biotech | 96T | EUR 600 |
GRO, KC, CXCL1, rRtGRO, rat |
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| RC352-12 | Bio Basic | 5ug | EUR 125.26 |
GRO/KC (CXCL1), Rat Recombinant |
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| P1288-25 | Biovision | each | EUR 444 |
GRO/KC (CXCL1), Rat Recombinant |
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| P1288-5 | Biovision | each | EUR 210 |
Rabbit Anti Mouse Cxcl1 Polyclonal Antibody |
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| CPBT-65100RM | Creative Diagnostics | 0.1 mg | EUR 1057.2 |
Recombinant Murine KC (CXCL1) Protein |
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| PROTP12850-2 | BosterBio | 20ug | EUR 380.4 |
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Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2. |
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Recombinant Rat GRO/KC (CXCL1) Protein |
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| PROTP14095-1 | BosterBio | 25ug | EUR 380.4 |
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Description: All three isoforms of GRO are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant rat GRO/KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2. |
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Rat CXCL1/CINC-1/KC ELISA Kit |
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| RK00196 | Abclonal | 96 Tests | EUR 625.2 |
Mouse CXCL1 ELISA Kit |
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| 55R-1741 | Fitzgerald | 1 kit | EUR 748.8 |
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Description: ELISA kit for detection of CXCL1 in the research laboratory |
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Mouse CXCL1 shRNA Plasmid |
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| 20-abx970673 | Abbexa |
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GRO-alpha/CXCL1, Mouse |
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| HY-P7188 | MedChemExpress | 50ug | EUR 639.6 |
ELISA kit for Mouse CXCL1 |
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| EK5299 | SAB | 96 tests | EUR 663.6 |
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Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse CXCL1 in samples from serum, plasma, tissue homogenates and other biological fluids. |
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Mouse CXCL1/GROα ELISA kit |
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| LF-EK50473 | Abfrontier | 1×96T | EUR 777.6 |
Mouse CXCL1 AssayLite Antibody (FITC Conjugate) |
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| 70027-05141 | AssayPro | 150 ug | EUR 513.6 |
Mouse CXCL1 PicoKine ELISA Kit |
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| EK0723 | BosterBio | 96 wells | EUR 547.2 |
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Description: For quantitative detection of mouse CXCL1 in cell culture supernates and serum. |
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Mouse CXCL1 Detection Assay Kit |
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| 6725 | Chondrex | 1 kit | EUR 580.26 |
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Description: Mouse CXCL1 Detection Assay Kit |
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CXCL1 protein (Mouse) (His tag) |
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| 80R-3368 | Fitzgerald | 50 ug | EUR 308.4 |
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Description: Purified recombinant CXCL1 protein (Mouse) (His tag) |
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CXCL1 protein (Mouse) (His tag) |
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| 80R-3439 | Fitzgerald | 50 ug | EUR 308.4 |
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Description: Purified recombinant CXCL1 protein (Mouse) (His tag) |
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Cxcl1 ORF Vector (Mouse) (pORF) |
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| ORF042286 | ABM | 1.0 ug DNA | EUR 114 |
CXCL1 ELISA Kit (Mouse) (OKCD05712) |
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| OKCD05712 | Aviva Systems Biology | 96 Wells | EUR 730.8 |
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Description: Description of target: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 6.0pg/mL |
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CXCL1 ELISA Kit (Mouse) (OKBB00312) |
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| OKBB00312 | Aviva Systems Biology | 96 Tests | EUR 652.8 |
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Description: Description of target: Chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROα, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-α). In humans, this protein is encoded by the CXCL1 gene. The gene for CXCL1 is located on human chromosome 4 amongst genes for other CXC chemokines. The mature form of CXCL1 is maximally 73 amino acids long. CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. CXCL1 is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. This chemokine elicits its effects by signaling through the chemokine receptor CXCR2.CXCL1 decreased the severity of multiple sclerosis and may offer a neuro-protective function. The standard product used in this kit is recombinant mouse CXCL1, consisting of 77 amino acids with the molecular mass of 8KDa.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 1 pg/ml |
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CXCL1 ELISA Kit (Mouse) (OKAN04583) |
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| OKAN04583 | Aviva Systems Biology | 96 Wells | EUR 950.4 |
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Description: Description of target: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.0 pg/mL |
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Mouse CXCL1/GROα ELISA kit (4X96T) |
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| LF-EK50474 | Abfrontier | 4×96T | EUR 2641.2 |
Anti-GRO alpha/Cxcl1 Antibody |
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| A00533 | BosterBio | 100ug/vial | EUR 352.8 |
Anti-GRO alpha/CXCL1 Antibody |
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| PA1760 | BosterBio | 100ug/vial | EUR 352.8 |
GRO-alpha/CXCL1 (CHO-expressed), Mouse |
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| HY-P7186 | MedChemExpress | 50ug | EUR 404.4 |
Cxcl1 sgRNA CRISPR Lentivector set (Mouse) |
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| K4368201 | ABM | 3 x 1.0 ug | EUR 406.8 |
CXCL1 antibody |
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| 70R-10502 | Fitzgerald | 50 ug | EUR 560.4 |
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Description: Affinity purified rabbit polyclonal CXCL1 antibody |
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CXCL1 Antibody |
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| 43679-100ul | SAB | 100ul | EUR 302.4 |
CXCL1 antibody |
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| 70R-16681 | Fitzgerald | 50 ul | EUR 522 |
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Description: Rabbit polyclonal CXCL1 antibody |
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CXCL1 antibody |
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| 70R-14297 | Fitzgerald | 100 ug | EUR 392.4 |
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Description: Affinity purified Rabbit polyclonal CXCL1 antibody |
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CXCL1 antibody |
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| 70R-15473 | Fitzgerald | 100 ug | EUR 392.4 |
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Description: Rabbit polyclonal CXCL1 antibody |
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CXCL1 Antibody |
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| 33054-100ul | SAB | 100ul | EUR 302.4 |
CXCL1 Antibody |
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| 1-CSB-PA009036 | Cusabio |
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Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000 |
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Cxcl1 Antibody |
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| 1-CSB-PA09217A0Rb | Cusabio |
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Description: A polyclonal antibody against Cxcl1. Recognizes Cxcl1 from Mouse. This antibody is Unconjugated. Tested in the following application: ELISA |
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CXCL1 Antibody |
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| 1-CSB-PA006239GA01HU | Cusabio |
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Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC |
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CXCL1 Antibody |
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| 1-CSB-PA06097A0Rb | Cusabio |
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Description: A polyclonal antibody against CXCL1. Recognizes CXCL1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA |
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Nori® Mouse CXCL1/GRO-alpha ELISA Kit |
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| GR117324 | Genorise Scientific | 96-well | EUR 461 |
CXCL1 Protein Vector (Mouse) (pPM-C-HA) |
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| PV169144 | ABM | 500 ng | EUR 723.6 |
Mouse Growth-regulated alpha protein (Cxcl1) |
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| 1-CSB-RP092174m | Cusabio |
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Description: Recombinant Mouse Growth-regulated alpha protein(Cxcl1),partial expressed in E.coli |
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Cxcl1 ELISA Kit (Mouse) : 96 Wells (OKEH02714) |
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| OKEH02714 | Aviva Systems Biology | 96 Wells | EUR 652.8 |
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Description: Description of target: This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. ;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 15.76 pg/mL |
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CXCL1 Protein Vector (Mouse) (pPB-C-His) |
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| PV169142 | ABM | 500 ng | EUR 723.6 |
CXCL1 Protein Vector (Mouse) (pPB-N-His) |
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| PV169143 | ABM | 500 ng | EUR 723.6 |
CXCL1 Protein Vector (Mouse) (pPM-C-His) |
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| PV169145 | ABM | 500 ng | EUR 723.6 |
Cxcl1 sgRNA CRISPR Lentivector (Mouse) (Target 1) |
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| K4368202 | ABM | 1.0 ug DNA | EUR 184.8 |
Cxcl1 sgRNA CRISPR Lentivector (Mouse) (Target 2) |
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| K4368203 | ABM | 1.0 ug DNA | EUR 184.8 |
Cxcl1 sgRNA CRISPR Lentivector (Mouse) (Target 3) |
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| K4368204 | ABM | 1.0 ug DNA | EUR 184.8 |
CXCL1 antibody (HRP) |
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| 60R-2236 | Fitzgerald | 100 ug | EUR 392.4 |
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Description: Rabbit polyclonal CXCL1 antibody (HRP) |
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CXCL1 antibody (FITC) |
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| 60R-2237 | Fitzgerald | 100 ug | EUR 392.4 |
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Description: Rabbit polyclonal CXCL1 antibody (FITC) |
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Rabbit Anti Rat Cxcl1 Polyclonal Antibody |
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| CPBT-65101RR | Creative Diagnostics | 0.1 mg | EUR 1057.2 |
Mouse Cxcl1/ Growth-regulated alpha protein ELISA Kit |
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| E0354Mo | Sunlong | 1 Kit | EUR 655.2 |
CXCL1 Chemi-Luminescent ELISA Kit (Mouse) (OKCD03823) |
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| OKCD03823 | Aviva Systems Biology | 96 Wells | EUR 1232.4 |
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Description: Description of target: Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation . Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity.;Species reactivity: Mouse;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 15.6 pg/mL |
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CXCL1 antibody (biotin) |
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| 60R-2238 | Fitzgerald | 100 ug | EUR 392.4 |
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Description: Rabbit polyclonal CXCL1 antibody (biotin) |
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Cxcl1 Polyclonal Antibody |
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| A51950 | EpiGentek |
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CXCL1 Polyclonal Antibody |
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| A51978 | EpiGentek |
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CXCL1 Conjugated Antibody |
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| C33054 | SAB | 100ul | EUR 476.4 |
Mouse Growth regulated alpha protein, Cxcl1 ELISA KIT |
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| ELI-04012m | Lifescience Market | 96 Tests | EUR 1038 |
CXCL1/GRO |
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| E21-597 | EnoGene | 10ug | EUR 411.6 |
CXCL1/GRO |
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| EF012822 | Lifescience Market | 96 Tests | EUR 826.8 |
CXCL1 siRNA |
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| 20-abx913248 | Abbexa |
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CXCL1 siRNA |
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| 20-abx913249 | Abbexa |
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CXCL1 siRNA |
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| 20-abx901350 | Abbexa |
|
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pEGFP- CXCL1 |
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| PVT10178 | Lifescience Market | 2 ug | EUR 361.2 |
Mouse Growth-Regulated Alpha Protein (CXCL1) ELISA Kit |
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| 20-abx154438 | Abbexa |
|
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Mouse Growth-Regulated Alpha Protein (CXCL1) ELISA Kit |
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| abx050043-96tests | Abbexa | 96 tests | EUR 924 |
Mouse Growth-Regulated Alpha Protein (CXCL1) ELISA Kit |
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| abx253956-96tests | Abbexa | 96 tests | EUR 801.6 |
Mouse Growth-Regulated Alpha Protein (CXCL1) ELISA Kit |
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| abx574645-96tests | Abbexa | 96 tests | EUR 801.6 |
Mouse CXCL1/GROα(Growth Regulated Oncogene Alpha) ELISA Kit |
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| EM0003 | FN Test | 96T | EUR 571.5 |
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Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 9.375pg/ml |
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CXCL1 protein |
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| 30R-3156 | Fitzgerald | 50 ug | EUR 308.4 |
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Description: Purified recombinant CXCL1 protein |
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CXCL1 Peptide |
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| 42-129P | ProSci | 0.1 mg | EUR 405.6 |
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Description: (CT) CXCL1 Peptide |
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GRO alpha (CXCL1) Antibody |
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| abx018005-100ug | Abbexa | 100 ug | EUR 410.4 |
Gro alpha Antibody / CXCL1 |
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| RQ4031 | NSJ Bioreagents | 100 ug | EUR 356.15 |
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Description: CXCL1 (Chemokine, CXC motif, Ligand 1), also called GRO1, SCYB1, GROA or MGSA, is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GRO?, KC, Neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MSGA-?). In humans, this protein is encoded by the CXCL1 gene. The CXCL1 gene is mapped on 4q13.3. CXCL1 is secreted by human melanoma cells, has mitogenic properties and is implicated in melanoma pathogenesis. It is expressed by macrophages, neutrophils and epithelial cells, and has neutrophil chemoattractant activity. CXCL1 plays a role in spinal cord development by inhibiting the migration of oligodendrocyte precursors and is involved in the processes of angiogenesis, inflammation, wound healing, and tumorigenesis. Signaling through Cxcr2, Cxcl1 inhibited oligodendrocyte precursor migration. The migrational arrest was rapid, reversible, and concentration dependent, and it reflected enhanced cell/substrate interactions. White matter expression of Cxcl1 was temporospatially regulated. Others contribute to aggressive growth selectivity in the lung. Among the lung metastasis signature genes identified, several, including CXCL1, were functionally validated. |
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Recombinant Mouse CXCL1/ MGSA/ NAP-3 Protein, His, E.coli-1mg |
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| QP8650-ec-1mg | EnQuireBio | 1mg | EUR 2763.6 |
Recombinant Mouse CXCL1/ MGSA/ NAP-3 Protein, His, E.coli-10ug |
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| QP8650-ec-10ug | EnQuireBio | 10ug | EUR 326.4 |
Recombinant Mouse CXCL1/ MGSA/ NAP-3 Protein, His, E.coli-50ug |
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| QP8650-ec-50ug | EnQuireBio | 50ug | EUR 434.4 |
Recombinant Mouse CXCL1/ GRO-alpha Protein, Untagged, E.coli-1mg |
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| QP1455-1mg | EnQuireBio | 1mg | EUR 3427.2 |
Recombinant Mouse CXCL1/ GRO-alpha Protein, Untagged, E.coli-5ug |
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| QP1455-5ug | EnQuireBio | 5ug | EUR 163.2 |
Recombinant Mouse CXCL1/ MGSA/ NAP-3 Protein, His, E.coli-100ug |
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| QP8650-ec-100ug | EnQuireBio | 100ug | EUR 685.2 |
Recombinant Mouse CXCL1/ MGSA/ NAP-3 Protein, His, E.coli-200ug |
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| QP8650-ec-200ug | EnQuireBio | 200ug | EUR 1077.6 |
Recombinant Mouse CXCL1/ MGSA/ NAP-3 Protein, His, E.coli-500ug |
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| QP8650-ec-500ug | EnQuireBio | 500ug | EUR 1816.8 |
Recombinant Mouse CXCL1/ GRO-alpha Protein, Untagged, E.coli-20ug |
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| QP1455-20ug | EnQuireBio | 20ug | EUR 284.4 |