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Identification of potential anti-TMPRSS2 pure merchandise by homology

Identification of potential anti-TMPRSS2 pure merchandise by homology modelling, digital screening and molecular dynamics simulation research
Latest outbreak of extreme acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to a pandemic of COVID-19.
The absence of a therapeutic drug and vaccine is inflicting extreme lack of life and financial system worldwide. SARS-CoV and SARS-CoV-2 make use of the host mobile serine protease TMPRSS2 for spike (S) protein priming for viral entry into host cells.
A potential solution to cut back the preliminary web site of SARS-CoV-2 an infection could also be to inhibit the exercise of TMPRSS2. Within the present research, the three-dimensional construction of TMPRSS2 was generated by homology modelling and subsequently validated with quite a lot of parameters.
The structure-based digital screening of Selleckchem database was carried out by ‘Digital Work Movement’ (VSW) to search out out potential lead-like TMPRSS2 inhibitors.
Camostat and bromhexine are recognized TMPRSS2 inhibitor medication, therefore these have been used as management molecules all through the research.
Primarily based on higher dock rating, binding-free power and binding interactions in comparison with the management molecules, six molecules (Neohesperidin, Myricitrin, Quercitrin, Naringin, Icariin, and Ambroxol) have been discovered to be promising towards the TMPRSS2.
Binding interactions evaluation revealed quite a lot of vital binding interactions with binding web site amino residues of TMPRSS2.
The all-atoms molecular dynamics (MD) simulation research indicated that every one proposed molecules retain contained in the receptor in dynamic states.
The binding power calculated from the MD simulation trajectories additionally favour the robust affinity of the molecules in direction of the TMPRSS2.
Proposed molecules belong to the bioflavonoid class of phytochemicals and are reported to own antiviral exercise, our research signifies their attainable potential for software in COVID-19. Communicated by Ramaswamy H. Sarma.
Key phrases: COVID-19; SARS-CoV-2; TMPRSS2; molecular docking; molecular dynamics; pure merchandise; digital screening.

Molecular Targets of Pure Merchandise for Chondroprotection in Harmful Joint Ailments
Osteoarthritis (OA) is the commonest kind of arthritis that happens in an aged inhabitants. It impacts any joints within the physique and degenerates the articular cartilage and the subchondral bone.
Regardless of the pathophysiology of OA being completely different, cartilage resorption remains to be a logo of osteoarthritis. Matrix metalloproteinases (MMPs) are essential proteolytic enzymes that degrade extra-cellular matrix proteins (ECM) within the physique.
MMPs contribute to the turnover of cartilage and its break down; their ranges have elevated within the joint tissues of OA sufferers.
Utility of chondroprotective medication neutralize the actions of MMPs.
Pure merchandise derived from herbs and vegetation developed as conventional drugs have been paid consideration to, due to their potential organic results.
The therapeutic worth of pure merchandise in OA has elevated in repute attributable to their scientific influence and insignificant negative effects.
A number of MMPs inhibitor have been used as therapeutic medication, for a very long time. Just lately, several types of compounds have been reviewed for his or her organic actions.
On this overview, we summarize quite a few pure merchandise for the event of MMPs inhibitors in arthritic illnesses and describe the key signaling targets that have been concerned for the remedies of those harmful joint illnesses.
Key phrases: MMPs; arthritis; chondroprotection; pure merchandise; signaling pathways.
Molecular and in vitro evaluation of some probiotic traits of amylolytic Lactobacillus plantarum strains from Bulgarian fermented merchandise
Within the latest years, shoppers’ curiosity in nutritious diet opened a brand new discipline for useful meals improvement by combining the invaluable composition of cereals and the health-promoting properties of lactic acid micro organism (LAB).
LAB with amylolytic properties can assimilate starch in a single-step course of and might be efficiently utilized as starter cultures providing an environment friendly dietary conversion of cereal matrices.
The probiotic potential of amylolytic LAB has not been investigated to this point, subsequently the current research targeted on the molecular screening and in vitro exams of 5 amylolytic Lactobacillus plantarum strains to evaluate their tolerance to excessive acid and bile salts concentrations and antibiotic resistance as primary traits required for probiotic strains choice.
Outcomes confirmed wonderful correspondence between the genetic screening and the phenotypic exams carried out.
Survivability at excessive acidity and bile salts presence was pressure particular, with vital optimistic impact noticed for cultures in stationary part in comparison with these in exponential part.
Impact of starch within the medium proved most essential to make sure viability of the amylolytic strains, which reveals the wonderful potential of amylolytic LAB for commercially related probiotic purposes.
The strains proved to be usually secure when it comes to antibiotic resistance. Among the many 5 examined strains, L. plantarum Bom2 confirmed the most effective probiotic potential.
Key phrases: Amylolytic lactic acid micro organism; In vitro evaluation; Lactobacillus plantarum; Molecular screening; Probiotic properties.
Canine TGFR ELISA Kit |
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ECT0062 | Abclonal | 96Tests | EUR 625.2 |
Porcine TGFR ELISA Kit |
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EPT0062 | Abclonal | 96Tests | EUR 625.2 |
Chicken TGFR ELISA Kit |
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ECKT0062 | Abclonal | 96Tests | EUR 625.2 |
Anserini TGFR ELISA Kit |
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EAT0062 | Abclonal | 96Tests | EUR 625.2 |
Guinea Pig TGFR ELISA Kit |
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EGT0062 | Abclonal | 96Tests | EUR 625.2 |
Recombinant Human ALK-1 Protein |
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RP00978 | Abclonal | 5 μg | EUR 163.2 |
Recombinant Human ALK-1 Protein |
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VAng-2860Lsx-10g | Creative Biolabs | 10 µg | EUR 736.8 |
Description: Recombinant Human ALK-1 was expressed in Sf9 Insect Cells. (Uniprot ID: P37023) |
Recombinant Human ALK-1 Protein |
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VAng-2860Lsx-1mg | Creative Biolabs | 1 mg | EUR 16605.6 |
Description: Recombinant Human ALK-1 was expressed in Sf9 Insect Cells. (Uniprot ID: P37023) |
Goat anti Human IgG (Alk Phos) |
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43C-CB0963 | Fitzgerald | 1 mg | EUR 433.2 |
Description: Goat anti Human IgG secondary antibody (Alk Phos) |
Goat anti Human IgG (Alk Phos) |
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43C-CB0978 | Fitzgerald | 1 mg | EUR 483.6 |
Description: Goat anti Human IgG secondary antibody (Alk Phos) |
Goat anti Human IgM (Alk Phos) |
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43C-CB0999 | Fitzgerald | 1 mg | EUR 456 |
Description: Goat anti Human IgM secondary antibody (Alk Phos) |
Goat anti Human IgG (Alk Phos) |
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43R-1169 | Fitzgerald | 1 mg | EUR 223.2 |
Description: Goat anti Human IgG secondary antibody (Alk Phos) |
Goat anti Human IgG (Alk Phos) |
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43R-1175 | Fitzgerald | 1 mg | EUR 268.8 |
Description: Goat anti Human IgG secondary antibody (Alk Phos) |
Goat anti Human IgG (Alk Phos) |
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43R-1192 | Fitzgerald | 1 mg | EUR 315.6 |
Description: Goat anti Human IgG secondary antibody (Alk Phos) |
Goat anti Human IgG (Alk Phos) |
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43R-1204 | Fitzgerald | 500 ug | EUR 355.2 |
Description: Goat anti Human IgG secondary antibody (Alk Phos) |
Goat anti Human IgG (Alk Phos) |
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43R-IG012alk | Fitzgerald | 1 ml | EUR 658.8 |
Description: Goat anti Human IgG secondary antibody (Alk Phos) |
Goat anti Human IgG (Alk Phos) |
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43R-IG165ALK | Fitzgerald | 1 mg | EUR 268.8 |
Description: Goat anti Human IgG secondary antibody (Alk Phos) |
Rabbit anti Human IgG (Alk Phos) |
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43C-CB0949 | Fitzgerald | 1 mg | EUR 526.8 |
Description: Rabbit anti Human IgG secondary antibody (Alk Phos) |
Rabbit anti Human IgG (Alk Phos) |
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43C-CB0956 | Fitzgerald | 1 mg | EUR 450 |
Description: Rabbit anti Human IgG secondary antibody (Alk Phos) |
Rabbit anti Human IgG (Alk Phos) |
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43C-CB0970 | Fitzgerald | 1 mg | EUR 450 |
Description: Rabbit anti Human IgG secondary antibody (Alk Phos) |
Rabbit anti Human IgM (Alk Phos) |
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43C-CB9106 | Fitzgerald | 1 mg | EUR 522 |
Description: Rabbit anti Human IgM secondary antibody (Alk Phos) |
Rabbit anti Human IgA (Alk Phos) |
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43C-CB9120 | Fitzgerald | 1 mg | EUR 475.2 |
Description: Rabbit anti Human IgA secondary antibody (Alk Phos) |
Goat anti Human IgG Fc (Alk Phos) |
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43-I24 | Fitzgerald | 100 ug | EUR 198 |
Description: Goat anti Human IgG Fc secondary antibody (Alk Phos) |
Goat anti Human Kappa Chain (Alk Phos) |
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43C-CB9127 | Fitzgerald | 1 mg | EUR 500.4 |
Description: Goat anti Human Kappa Chain secondary antibody (Alk Phos) |
Goat anti Human kappa chain (Alk Phos) |
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43R-1257 | Fitzgerald | 500 ug | EUR 482.4 |
Description: Goat anti Human kappa chain secondary antibody (Alk Phos) |
Nori® Human ALK-1 ELISA Kit |
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GR111542 | Genorise Scientific | 96-well | EUR 461 |
Goat anti Human Lambda Chain (Alk Phos) |
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43C-CB9134 | Fitzgerald | 1 mg | EUR 500.4 |
Description: Goat anti Human Lambda Chain secondary antibody (Alk Phos) |
Human ALK and LTK ligand 1 (ALKAL1) |
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1-CSB-EP757795HU | Cusabio |
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Description: Recombinant Human ALK and LTK ligand 1(ALKAL1) expressed in E.coli |
ELISA kit for Human ALK-1/ACVRL1 |
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EK5715 | SAB | 96 tests | EUR 663.6 |
Description: Enzyme-linked immunosorbent assay kit for quantification of Human ALK-1/ACVRL1 in samples from serum, plasma, tissue homogenates and other biological fluids. |
ALK-1 Polyclonal Antibody |
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ABP52913-003ml | Abbkine | 0.03ml | EUR 189.6 |
Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human ALK-1 |
ALK-1 Polyclonal Antibody |
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ABP52913-01ml | Abbkine | 0.1ml | EUR 346.8 |
Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human ALK-1 |
ALK-1 Polyclonal Antibody |
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ABP52913-02ml | Abbkine | 0.2ml | EUR 496.8 |
Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human ALK-1 |
ALK-1 Polyclonal Antibody |
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ABP57032-003ml | Abbkine | 0.03ml | EUR 189.6 |
Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ALK-1 at AA range: 170-250 |
ALK-1 Polyclonal Antibody |
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ABP57032-01ml | Abbkine | 0.1ml | EUR 346.8 |
Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ALK-1 at AA range: 170-250 |
ALK-1 Polyclonal Antibody |
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ABP57032-02ml | Abbkine | 0.2ml | EUR 496.8 |
Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ALK-1 at AA range: 170-250 |
ALK-1 Polyclonal Antibody |
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41591-100ul | SAB | 100ul | EUR 302.4 |
ALK-1 Polyclonal Antibody |
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41591-50ul | SAB | 50ul | EUR 224.4 |
ALK-1 Polyclonal Antibody |
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ES8031-100ul | ELK Biotech | 100ul | EUR 334.8 |
Description: A Rabbit Polyclonal antibody against ALK-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
ALK-1 Polyclonal Antibody |
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ES8031-50ul | ELK Biotech | 50ul | EUR 248.4 |
Description: A Rabbit Polyclonal antibody against ALK-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
ALK-1 Polyclonal Antibody |
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ES3912-100ul | ELK Biotech | 100ul | EUR 334.8 |
Description: A Rabbit Polyclonal antibody against ALK-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
ALK-1 Polyclonal Antibody |
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ES3912-50ul | ELK Biotech | 50ul | EUR 248.4 |
Description: A Rabbit Polyclonal antibody against ALK-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA |
Goat anti Human IgG (H + L) (Alk Phos) |
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43C-CB0921 | Fitzgerald | 1 mg | EUR 205.2 |
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
Goat anti Human IgG (H + L) (Alk Phos) |
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43C-CB0928 | Fitzgerald | 1 mg | EUR 417.6 |
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
Goat anti Human IgG (H + L) (Alk Phos) |
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43C-CB0935 | Fitzgerald | 1 mg | EUR 543.6 |
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
Goat anti Human IgG (H + L) (Alk Phos) |
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43R-1145 | Fitzgerald | 1 mg | EUR 268.8 |
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
Goat anti Human IgG (H + L) (Alk Phos) |
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43R-1157 | Fitzgerald | 500 ug | EUR 268.8 |
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
Goat anti Human IgG (H + L) (Alk Phos) |
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43R-1163 | Fitzgerald | 500 ug | EUR 315.6 |
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
Human ALK-1/ACVRL1 PicoKine ELISA Kit |
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EK1518 | BosterBio | 96 wells | EUR 510 |
Description: For quantitative detection of human ALK-1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). |
Rabbit anti Human IgG (H + L) (Alk Phos) |
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43-I23 | Fitzgerald | 1 mg | EUR 435.6 |
Description: Rabbit anti Human IgG (H + L) secondary antibody (Alk Phos) |
Rabbit anti Human IgG (H + L) (Alk Phos) |
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43C-CB0914 | Fitzgerald | 1 mg | EUR 478.8 |
Description: Rabbit anti Human IgG (H + L) secondary antibody (Alk Phos) |
Goat anti Human IgG + IgA + IgM (Alk Phos) |
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43R-1245 | Fitzgerald | 1 mg | EUR 205.2 |
Description: Goat anti Human IgG + IgA + IgM secondary antibody (Alk Phos) |
Goat anti Human IgG + IgA + IgM (Alk Phos) |
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43R-1251 | Fitzgerald | 500 ug | EUR 268.8 |
Description: Goat anti Human IgG + IgA + IgM secondary antibody (Alk Phos) |
Rabbit anti Human IgG (H + L) (Alk Phos) |
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43R-1269 | Fitzgerald | 1 mg | EUR 295.2 |
Description: Rabbit anti Human IgG (H + L) secondary antibody (Alk Phos) |
Donkey anti Human IgG (H + L) (Alk Phos) |
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43R-ID001alk | Fitzgerald | 500 ul | EUR 390 |
Description: Donkey anti Human IgG (H + L) secondary antibody (Alk Phos) |
Goat anti Human IgM (mu chain) (Alk Phos) |
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43-I34 | Fitzgerald | 1 mg | EUR 232.8 |
Description: Goat anti Human IgM (mu chain) secondary antibody (Alk Phos) |
Goat anti Human IgM (mu chain) (Alk Phos) |
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43R-1227 | Fitzgerald | 1 mg | EUR 274.8 |
Description: Goat anti Human IgM (mu chain) secondary antibody (Alk Phos) |
Goat anti Human IgM (mu chain) (Alk Phos) |
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43R-1233 | Fitzgerald | 500 ug | EUR 456 |
Description: Goat anti Human IgM (mu chain) secondary antibody (Alk Phos) |
Goat anti Human IgM (mu chain) (Alk Phos) |
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43R-1239 | Fitzgerald | 500 ug | EUR 456 |
Description: Goat anti Human IgM (mu chain) secondary antibody (Alk Phos) |
Goat anti Human IgA (alpha chain) (Alk Phos) |
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43-I10 | Fitzgerald | 1 mg | EUR 355.2 |
Description: Goat anti Human IgA (alpha chain) secondary antibody (Alk Phos) |
Goat anti Human IgA (alpha chain) (Alk Phos) |
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43R-1119 | Fitzgerald | 500 ug | EUR 355.2 |
Description: Goat anti Human IgA (alpha chain) secondary antibody (Alk Phos) |
Goat anti Human IgG (gamma chain) (Alk Phos) |
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43R-1659 | Fitzgerald | 1 mg | EUR 301.2 |
Description: Goat anti Human IgG (gamma chain) secondary antibody (Alkaline Phosphatase) |
Goat anti Human IgE (epsilon chain) (Alk Phos) |
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43R-1129 | Fitzgerald | 1 mg | EUR 456 |
Description: Goat anti Human IgE (epsilon chain) secondary antibody (Alk Phos) |
Goat anti Human IgE (epsilon chain) (Alk Phos) |
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43R-1134 | Fitzgerald | 500 ug | EUR 456 |
Description: Goat anti Human IgE (epsilon chain) secondary antibody (Alk Phos) |
Goat Anti Human Ige Polyclonal Antibody,Alk. Phos. |
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CPBT-65486GH | Creative Diagnostics | 0.5 mg | EUR 696 |
Recombinant Human ALK-1 Protein (aa 22-503) |
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VAng-2854Lsx-100g | Creative Biolabs | 100 µg | EUR 8440.8 |
Description: Recombinant Human ALK-1 was expressed in cell free expression systems. (Uniprot ID: P37023) |
Recombinant Human ALK-1 Protein (aa 22-503) |
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VAng-2854Lsx-50g | Creative Biolabs | 50 µg | EUR 5454 |
Description: Recombinant Human ALK-1 was expressed in cell free expression systems. (Uniprot ID: P37023) |
Recombinant Human ALK-1 Protein (aa 22-118) |
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VAng-2856Lsx-1mg | Creative Biolabs | 1 mg | EUR 3393.6 |
Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023) |
Recombinant Human ALK-1 Protein (aa 22-118) |
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VAng-2856Lsx-200g | Creative Biolabs | 200 µg | EUR 2205.6 |
Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023) |
Recombinant Human ALK-1 Protein (aa 22-118) |
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VAng-2856Lsx-500g | Creative Biolabs | 500 µg | EUR 2419.2 |
Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023) |
Anti-ALK Antibody Clone ALK/1503, Unconjugated-20ug |
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238-MSM3-P0 | EnQuireBio | 20ug | EUR 279.6 |
Anti-ALK Antibody Clone ALK/1503, Unconjugated-100ug |
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238-MSM3-P1 | EnQuireBio | 100ug | EUR 513.6 |
ALK-1 Polyclonal Conjugated Antibody |
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C41591 | SAB | 100ul | EUR 476.4 |
ALK-IN-1 |
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HY-13464 | MedChemExpress | 100mg | EUR 472.8 |
Goat anti Human IgG + IgA + IgM (H + L) (Alk Phos) |
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43C-CB0992 | Fitzgerald | 1 mg | EUR 462 |
Description: Goat anti Human IgG + IgA + IgM (H + L) secondary antibody (Alk Phos) |
ALK sgRNA CRISPR Lentivector (Human) (Target 1) |
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K0074502 | ABM | 1.0 ug DNA | EUR 184.8 |
Goat Anti Human Igg (Fc) Polyclonal Antibody,Alk. Phos. |
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CPBT-65492GH | Creative Diagnostics | 1 mg | EUR 920.4 |
ALK inhibitor 1 |
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HY-15357 | MedChemExpress | 50mg | EUR 1712.4 |
Recombinant Human ALK-1 Protein (aa 22-118) [Fc] |
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VAng-2859Lsx-50g | Creative Biolabs | 50 µg | EUR 621.6 |
Description: Recombinant Human ALK-1 was expressed in HEK 293 cells. (Uniprot ID: P37023) |
Recombinant Human ALK-1 Protein (aa 238-479) [His] |
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VAng-2861Lsx-1mg | Creative Biolabs | 1 mg | EUR 3952.8 |
Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023) |
Recombinant Human ALK-1 Protein (aa 238-479) [His] |
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VAng-2861Lsx-200g | Creative Biolabs | 200 µg | EUR 1429.2 |
Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023) |
Recombinant Human ALK-1 Protein (aa 238-479) [His] |
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VAng-2861Lsx-500g | Creative Biolabs | 500 µg | EUR 2700 |
Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023) |
Human Albumin antibody (Alk Phos) |
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60R-AG004ALK | Fitzgerald | 1 mg | EUR 418.8 |
Description: Human Albumin antibody (Alk Phos) |
Antibody for Human ALK (pTyr1092) |
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SPC-912D-STR | Stressmarq | 0.1ml | EUR 477.6 |
Description: A polyclonal antibody for ALK (pTyr1092) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Tyr1092 of human ALK (AA1504-1510). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ALK (pTyr1092) antibody is conjugated to Streptavidin. |
Antibody for Human ALK (pTyr1507) |
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SPC-913D | Stressmarq | 0.1ml | EUR 424.8 |
Description: A polyclonal antibody for ALK (pTyr1507) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Tyr1507 of human ALK (AA374-382). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ALK (pTyr1507) antibody is unconjugated. |
Antibody for Human ALK (pTyr1507) |
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SPC-913D-A390 | Stressmarq | 0.1ml | EUR 481.2 |
Description: A polyclonal antibody for ALK (pTyr1507) from Human. The antibody is produced in rabbit after immunization with Human A phospho-specific peptide corresponding to residues surrounding Tyr1507 of human ALK (AA374-382). The Antibody is tested and validated for WB, AM assays with the following recommended dilutions: WB (1:250). This ALK (pTyr1507) antibody is conjugated to ATTO 390. |