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Identification of potential anti-TMPRSS2 pure merchandise by homology
Identification of potential anti-TMPRSS2 pure merchandise by homology modelling, digital screening and molecular dynamics simulation research
Latest outbreak of extreme acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to a pandemic of COVID-19.
The absence of a therapeutic drug and vaccine is inflicting extreme lack of life and financial system worldwide. SARS-CoV and SARS-CoV-2 make use of the host mobile serine protease TMPRSS2 for spike (S) protein priming for viral entry into host cells.
A potential solution to cut back the preliminary web site of SARS-CoV-2 an infection could also be to inhibit the exercise of TMPRSS2. Within the present research, the three-dimensional construction of TMPRSS2 was generated by homology modelling and subsequently validated with quite a lot of parameters.
The structure-based digital screening of Selleckchem database was carried out by ‘Digital Work Movement’ (VSW) to search out out potential lead-like TMPRSS2 inhibitors.
Camostat and bromhexine are recognized TMPRSS2 inhibitor medication, therefore these have been used as management molecules all through the research.
Primarily based on higher dock rating, binding-free power and binding interactions in comparison with the management molecules, six molecules (Neohesperidin, Myricitrin, Quercitrin, Naringin, Icariin, and Ambroxol) have been discovered to be promising towards the TMPRSS2.
Binding interactions evaluation revealed quite a lot of vital binding interactions with binding web site amino residues of TMPRSS2.
The all-atoms molecular dynamics (MD) simulation research indicated that every one proposed molecules retain contained in the receptor in dynamic states.
The binding power calculated from the MD simulation trajectories additionally favour the robust affinity of the molecules in direction of the TMPRSS2.
Proposed molecules belong to the bioflavonoid class of phytochemicals and are reported to own antiviral exercise, our research signifies their attainable potential for software in COVID-19. Communicated by Ramaswamy H. Sarma.
Key phrases: COVID-19; SARS-CoV-2; TMPRSS2; molecular docking; molecular dynamics; pure merchandise; digital screening.
Molecular Targets of Pure Merchandise for Chondroprotection in Harmful Joint Ailments
Osteoarthritis (OA) is the commonest kind of arthritis that happens in an aged inhabitants. It impacts any joints within the physique and degenerates the articular cartilage and the subchondral bone.
Regardless of the pathophysiology of OA being completely different, cartilage resorption remains to be a logo of osteoarthritis. Matrix metalloproteinases (MMPs) are essential proteolytic enzymes that degrade extra-cellular matrix proteins (ECM) within the physique.
MMPs contribute to the turnover of cartilage and its break down; their ranges have elevated within the joint tissues of OA sufferers.
Utility of chondroprotective medication neutralize the actions of MMPs.
Pure merchandise derived from herbs and vegetation developed as conventional drugs have been paid consideration to, due to their potential organic results.
The therapeutic worth of pure merchandise in OA has elevated in repute attributable to their scientific influence and insignificant negative effects.
A number of MMPs inhibitor have been used as therapeutic medication, for a very long time. Just lately, several types of compounds have been reviewed for his or her organic actions.
On this overview, we summarize quite a few pure merchandise for the event of MMPs inhibitors in arthritic illnesses and describe the key signaling targets that have been concerned for the remedies of those harmful joint illnesses.
Key phrases: MMPs; arthritis; chondroprotection; pure merchandise; signaling pathways.
Molecular and in vitro evaluation of some probiotic traits of amylolytic Lactobacillus plantarum strains from Bulgarian fermented merchandise
Within the latest years, shoppers’ curiosity in nutritious diet opened a brand new discipline for useful meals improvement by combining the invaluable composition of cereals and the health-promoting properties of lactic acid micro organism (LAB).
LAB with amylolytic properties can assimilate starch in a single-step course of and might be efficiently utilized as starter cultures providing an environment friendly dietary conversion of cereal matrices.
The probiotic potential of amylolytic LAB has not been investigated to this point, subsequently the current research targeted on the molecular screening and in vitro exams of 5 amylolytic Lactobacillus plantarum strains to evaluate their tolerance to excessive acid and bile salts concentrations and antibiotic resistance as primary traits required for probiotic strains choice.
Outcomes confirmed wonderful correspondence between the genetic screening and the phenotypic exams carried out.
Survivability at excessive acidity and bile salts presence was pressure particular, with vital optimistic impact noticed for cultures in stationary part in comparison with these in exponential part.
Impact of starch within the medium proved most essential to make sure viability of the amylolytic strains, which reveals the wonderful potential of amylolytic LAB for commercially related probiotic purposes.
The strains proved to be usually secure when it comes to antibiotic resistance. Among the many 5 examined strains, L. plantarum Bom2 confirmed the most effective probiotic potential.
Key phrases: Amylolytic lactic acid micro organism; In vitro evaluation; Lactobacillus plantarum; Molecular screening; Probiotic properties.
Sheep TGFR ELISA Kit |
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EST0062 | Abclonal | 96Tests | EUR 625.2 |
Mouse TGFR ELISA Kit |
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EMT0062 | Abclonal | 96Tests | EUR 625.2 |
Bovine TGFR ELISA Kit |
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EBT0062 | Abclonal | 96Tests | EUR 625.2 |
Canine TGFR ELISA Kit |
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ECT0062 | Abclonal | 96Tests | EUR 625.2 |
Monkey TGFR ELISA Kit |
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EMKT0062 | Abclonal | 96Tests | EUR 625.2 |
Rabbit TGFR ELISA Kit |
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ERTT0062 | Abclonal | 96Tests | EUR 625.2 |
Chicken TGFR ELISA Kit |
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ECKT0062 | Abclonal | 96Tests | EUR 625.2 |
Porcine TGFR ELISA Kit |
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EPT0062 | Abclonal | 96Tests | EUR 625.2 |
Anserini TGFR ELISA Kit |
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EAT0062 | Abclonal | 96Tests | EUR 625.2 |
Guinea Pig TGFR ELISA Kit |
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EGT0062 | Abclonal | 96Tests | EUR 625.2 |
Human ALK-1 Antibody Pair Set |
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ABPR-ZB169 | Creative Diagnostics | 5 plates, 15 plates | Ask for price |
Description: Quantitative determination of Human ALK-1 |
Recombinant Human ALK-1 Protein |
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VAng-2860Lsx-10g | Creative Biolabs | 10 µg | EUR 736.8 |
Description: Recombinant Human ALK-1 was expressed in Sf9 Insect Cells. (Uniprot ID: P37023) |
Recombinant Human ALK-1 Protein |
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VAng-2860Lsx-1mg | Creative Biolabs | 1 mg | EUR 16605.6 |
Description: Recombinant Human ALK-1 was expressed in Sf9 Insect Cells. (Uniprot ID: P37023) |
GOAT ANTI HUMAN IGG, INTACT IGG, ALK PHOS, 1 ML |
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9450431 | Lampire Biologicals Laboratories | 1ML | EUR 207.65 |
RABBIT ANTI HUMAN IGG, INTACT IGG, ALK PHOS, 1 ML |
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9450511 | Lampire Biologicals Laboratories | 1ML | EUR 228.15 |
Human ACVRL1 / ALK-1, Fc Tag |
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E24PHA006 | EnoGene | 50 μg | EUR 180 |
Human ACVRL1 / ALK-1, His Tag |
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E24PHA007 | EnoGene | 50 μg | EUR 225 |
Human ALK-1/ACVRL1 ELISA Kit |
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EK5715 | SAB | 96 tests | EUR 599 |
Goat anti Human IgG (Alk Phos) |
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43C-CB0963 | Fitzgerald | 1 mg | EUR 351 |
Description: Goat anti Human IgG secondary antibody (Alk Phos) |
Goat anti Human IgG (Alk Phos) |
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43C-CB0978 | Fitzgerald | 1 mg | EUR 394 |
Description: Goat anti Human IgG secondary antibody (Alk Phos) |
Goat anti Human IgM (Alk Phos) |
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43C-CB0999 | Fitzgerald | 1 mg | EUR 347 |
Description: Goat anti Human IgM secondary antibody (Alk Phos) |
Goat anti Human IgG (Alk Phos) |
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43R-1169 | Fitzgerald | 1 mg | EUR 167 |
Description: Goat anti Human IgG secondary antibody (Alk Phos) |
Goat anti Human IgG (Alk Phos) |
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43R-1175 | Fitzgerald | 1 mg | EUR 208 |
Description: Goat anti Human IgG secondary antibody (Alk Phos) |
Goat anti Human IgG (Alk Phos) |
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43R-1192 | Fitzgerald | 1 mg | EUR 250 |
Description: Goat anti Human IgG secondary antibody (Alk Phos) |
Goat anti Human IgG (Alk Phos) |
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43R-1204 | Fitzgerald | 500 ug | EUR 293 |
Description: Goat anti Human IgG secondary antibody (Alk Phos) |
Goat anti Human IgG (Alk Phos) |
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43R-IG012alk | Fitzgerald | 1 ml | EUR 522 |
Description: Goat anti Human IgG secondary antibody (Alk Phos) |
Goat anti Human IgG (Alk Phos) |
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43R-IG165ALK | Fitzgerald | 1 mg | EUR 208 |
Description: Goat anti Human IgG secondary antibody (Alk Phos) |
Rabbit anti Human IgG (Alk Phos) |
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43C-CB0949 | Fitzgerald | 1 mg | EUR 44 |
Description: Rabbit anti Human IgG secondary antibody (Alk Phos) |
Rabbit anti Human IgG (Alk Phos) |
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43C-CB0956 | Fitzgerald | 1 mg | EUR 387 |
Description: Rabbit anti Human IgG secondary antibody (Alk Phos) |
Rabbit anti Human IgG (Alk Phos) |
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43C-CB0970 | Fitzgerald | 1 mg | EUR 387 |
Description: Rabbit anti Human IgG secondary antibody (Alk Phos) |
Rabbit anti Human IgM (Alk Phos) |
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43C-CB9106 | Fitzgerald | 1 mg | EUR 425 |
Description: Rabbit anti Human IgM secondary antibody (Alk Phos) |
Rabbit anti Human IgA (Alk Phos) |
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43C-CB9120 | Fitzgerald | 1 mg | EUR 385 |
Description: Rabbit anti Human IgA secondary antibody (Alk Phos) |
Nori® Human ALK-1 ELISA Kit |
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GR111542 | Genorise Scientific | 96-well | EUR 461 |
Human ALK and LTK ligand 1 (ALKAL1) |
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1-CSB-EP757795HU | Cusabio |
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Description: Recombinant Human ALK and LTK ligand 1(ALKAL1) expressed in E.coli |
Anti-ACVRL1 / ALK-1 Reference Antibody (ascrinvacumab) |
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E24CHA111 | EnoGene | 100 μg | EUR 225 |
Description: Available in various conjugation types. |
Human ALK-1 / ACVRL1 Protein, His Tag |
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AL1-H5228 | ACROBIOSYSTEMS | 100ug | EUR 2140 |
Description: Human ALK-1, His Tag (AL1-H5228) is expressed from human 293 cells (HEK293). It contains AA Asp 22 - Gln 118 (Accession # P37023). |
GOAT ANTI HUMAN IGA, U CHAIN, INTACT IGG, ALK PHOS, 1 ML |
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9450381 | Lampire Biologicals Laboratories | 1ML | EUR 258.89 |
GOAT ANTI HUMAN IGG, FCY FRAG, INTACT IGG, ALK PHOS, 1 ML |
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9450581 | Lampire Biologicals Laboratories | 1ML | EUR 258.89 |
GOAT ANTI HUMAN IGM, FC5U FRAG, INTACT IGG, ALK PHOS, 1 ML |
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9450641 | Lampire Biologicals Laboratories | 1ML | EUR 269.14 |
ALK-1 Polyclonal Antibody |
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ABP57032-003ml | Abbkine | 0.03ml | EUR 189.6 |
Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ALK-1 at AA range: 170-250 |
ALK-1 Polyclonal Antibody |
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ABP57032-01ml | Abbkine | 0.1ml | EUR 346.8 |
Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ALK-1 at AA range: 170-250 |
ALK-1 Polyclonal Antibody |
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ABP57032-02ml | Abbkine | 0.2ml | EUR 496.8 |
Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ALK-1 at AA range: 170-250 |
ALK-1 Polyclonal Antibody |
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ABP52913-003ml | Abbkine | 0.03ml | EUR 189.6 |
Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human ALK-1 |
ALK-1 Polyclonal Antibody |
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ABP52913-01ml | Abbkine | 0.1ml | EUR 346.8 |
Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human ALK-1 |
ALK-1 Polyclonal Antibody |
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ABP52913-02ml | Abbkine | 0.2ml | EUR 496.8 |
Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human ALK-1 |
ALK-1 Polyclonal Antibody |
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41591-100ul | SAB | 100ul | EUR 302.4 |
ALK-1 Polyclonal Antibody |
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41591-50ul | SAB | 50ul | EUR 224.4 |
ALK-1 Polyclonal Antibody |
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E041591 | EnoGene | 100μg/100μl | EUR 255 |
Description: Available in various conjugation types. |
ALK-1 Polyclonal Antibody |
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E20-75182 | EnoGene | 100ug | EUR 225 |
Description: Available in various conjugation types. |
ALK-1 Polyclonal Antibody |
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E20-70198 | EnoGene | 100ug | EUR 225 |
Description: Available in various conjugation types. |
ALK-1 Polyclonal Antibody |
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E44H06624 | EnoGene | 100ul | EUR 255 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
ALK-1 Polyclonal Antibody |
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E44H03961 | EnoGene | 100ul | EUR 255 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
ALK-1 Antibody, Concentrate |
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MAB663C | Innovex | 0.2ml | EUR 475 |
Rabbit Anti-Human ALK-1 monoclonal antibody, clone S215 |
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CABT-ZB592 | Creative Diagnostics | 50 μl | EUR 520 |
Description: Rabbit |
Rabbit Anti-Human ALK-1 monoclonal antibody, clone S135 |
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CABT-ZB944 | Creative Diagnostics | 50 μl | EUR 520 |
Description: Rabbit |
Human ALK-1/ACVRL1 PicoKine ELISA Kit |
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EK1518 | BosterBio | 96 wells | EUR 510 |
Description: For quantitative detection of human ALK-1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA). |
OKRC00141-96W - ALK-1 ELISA Kit (Human) |
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OKRC00141-96W | Aviva Systems Biology | 96Wells | EUR 550 |
Goat anti Human IgG Fc (Alk Phos) |
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43-I24 | Fitzgerald | 100 ug | EUR 125 |
Description: Goat anti Human IgG Fc secondary antibody (Alk Phos) |
Recombinant Human ALK-1 Protein, His Tag |
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E40KMP1394 | EnoGene | 20ug | EUR 495 |
Anti-ALK-1 antibody |
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STJ96547 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to ALK-1. |
Anti-ALK-1 antibody |
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STJ91563 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to ALK-1. |
Active Recombinant Human ALK-1/ACVRL1 Protein |
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RP00978 | Abclonal | 5 μg | EUR 39 |
Goat anti Human Kappa Chain (Alk Phos) |
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43C-CB9127 | Fitzgerald | 1 mg | EUR 403 |
Description: Goat anti Human Kappa Chain secondary antibody (Alk Phos) |
Goat anti Human kappa chain (Alk Phos) |
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43R-1257 | Fitzgerald | 500 ug | EUR 398 |
Description: Goat anti Human kappa chain secondary antibody (Alk Phos) |
Goat anti Human Lambda Chain (Alk Phos) |
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43C-CB9134 | Fitzgerald | 1 mg | EUR 403 |
Description: Goat anti Human Lambda Chain secondary antibody (Alk Phos) |
ALK-IN-1 |
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HY-13464 | MedChemExpress | 100mg | EUR 472.8 |
ALK-IN-1 |
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T3059-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: ALK-IN-1 |
ALK-IN-1 |
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T3059-1g | TargetMol Chemicals | 1g | Ask for price |
Description: ALK-IN-1 |
ALK-IN-1 |
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T3059-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: ALK-IN-1 |
ALK-IN-1 |
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T3059-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: ALK-IN-1 |
ALK-IN-1 |
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T3059-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: ALK-IN-1 |
ALK inhibitor 1 |
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HY-15357 | MedChemExpress | 50mg | EUR 1712.4 |
ALK inhibitor 1 |
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T10285-10mg | TargetMol Chemicals | 10mg | Ask for price |
Description: ALK inhibitor 1 |
ALK inhibitor 1 |
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T10285-1g | TargetMol Chemicals | 1g | Ask for price |
Description: ALK inhibitor 1 |
ALK inhibitor 1 |
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T10285-1mg | TargetMol Chemicals | 1mg | Ask for price |
Description: ALK inhibitor 1 |
ALK inhibitor 1 |
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T10285-50mg | TargetMol Chemicals | 50mg | Ask for price |
Description: ALK inhibitor 1 |
ALK inhibitor 1 |
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T10285-5mg | TargetMol Chemicals | 5mg | Ask for price |
Description: ALK inhibitor 1 |
Goat anti Human IgG (H + L) (Alk Phos) |
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43C-CB0921 | Fitzgerald | 1 mg | EUR 152 |
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
Goat anti Human IgG (H + L) (Alk Phos) |
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43C-CB0928 | Fitzgerald | 1 mg | EUR 349 |
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
Goat anti Human IgG (H + L) (Alk Phos) |
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43C-CB0935 | Fitzgerald | 1 mg | EUR 464 |
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
Goat anti Human IgG (H + L) (Alk Phos) |
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43R-1145 | Fitzgerald | 1 mg | EUR 208 |
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
Goat anti Human IgG (H + L) (Alk Phos) |
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43R-1157 | Fitzgerald | 500 ug | EUR 208 |
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
Goat anti Human IgG (H + L) (Alk Phos) |
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43R-1163 | Fitzgerald | 500 ug | EUR 250 |
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos) |
Sheep Polyclonal anti-human TGF beta RI (ALK-5) |
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hAP-5571 | Angio Proteomie | 50ug | EUR 400 |
Recombinant Human ALK-1 Protein (aa 22-503) |
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VAng-2854Lsx-100g | Creative Biolabs | 100 µg | EUR 8440.8 |
Description: Recombinant Human ALK-1 was expressed in cell free expression systems. (Uniprot ID: P37023) |