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Identification of low molecular weight degradation merchandise from chitin and chitosan

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Identification of low molecular weight degradation merchandise from chitin and chitosan by electrospray ionization time-of-flight mass spectrometry

The helpful results offered by chitosan oligosaccharides (COS) make them of curiosity in medical analysis.
The monomers that represent COS confer distinct properties, so controlling COS composition throughout their manufacturing is important.
On this work, we degraded chitin and chitosan polymers and recognized low molecular weight merchandise resembling COS that shaped, utilizing electrospray ionization time-of-flight mass spectrometry.
Our outcomes present that hydrochloric acid, hydrogen peroxide, and nitrous acid generate distinct merchandise from chitin and chitosan.
Hydrochloric acid degrades chitin and chitosan to provide glucosamine (GlcN) monomers and oligomers. Hydrogen peroxide degrades chitosan to provide GlcN and N-acetyl-d-glucosamine (GlcNAc) monomers and oligomers, and nitrous acid degrades chitosan to provide 2,5-anhydro- d-mannose.
Our research present that COS composition is dictated by each the degradation protocol and the beginning polymer. Moreover, our outcomes allow number of degradation protocols primarily based on their capacity to degrade chitin and chitosan and facilitate the manufacturing of COS with desired compositions.
Key phrases: Chitin; Chitosan; Mass spectrometry; Polysaccharide degradation.
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Phospho-Histone H3 (Thr3) Polyclonal Antibody
A-4051
  • EUR 684.66
  • EUR 423.50
  • 100 µg
  • 100 ul

Phospho-Histone H3 (Thr11) Polyclonal Antibody
A-4052
  • EUR 684.66
  • EUR 423.50
  • 100 µg
  • 100 ul

Rabbit Anti-Influenza A HA (H3N2, 1-531aa/HA1+HA2) (A/Brisbane/10/2007) protein IgG, aff pure
H3N23-A 100 ul
EUR 534

Influenza A H3 Antibody
abx021977-1mg 1 mg
EUR 1053.6

Influenza A H3 Antibody
abx021978-1mg 1 mg
EUR 1053.6

Influenza A antibody
10-1096 500 ug
EUR 249.6
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-1097 1 mg
EUR 418.8
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-1098 1 mg
EUR 726
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-1099 1 mg
EUR 726
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-1100 500 ug
EUR 418.8
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-1101 1 mg
EUR 726
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-1102 500 ug
EUR 418.8
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-1103 500 ug
EUR 418.8
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-1241 500 ug
EUR 418.8
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-1243 500 ug
EUR 418.8
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-7866 1 mg
EUR 483.6
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-7867 1 mg
EUR 483.6
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-I50A 1 mg
EUR 603.6
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-I50B 1 mg
EUR 470.4
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-I50C 1 mg
EUR 470.4
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-I50D 1 mg
EUR 334.8
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-I50E 1 mg
EUR 334.8
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-I50F 1 mg
EUR 327.6
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-I50G 1 mg
EUR 489.6
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-I50H 1 mg
EUR 649.2
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-I50I 1 mg
EUR 489.6
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-I50K 1 mg
EUR 327.6
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-I50L 1 mg
EUR 360
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-I50M 1 mg
EUR 360
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-I50N 1 mg
EUR 360
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-I50O 1 mg
EUR 360
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-I50P 1 mg
EUR 360
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-I50Q 1 mg
EUR 327.6
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-I50R 1 mg
EUR 327.6
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-I50S 1 mg
EUR 327.6
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-I50T 1 mg
EUR 327.6
Description: Mouse monoclonal Influenza A antibody

Influenza A antibody
10-I50U 1 mg
EUR 327.6
Description: Mouse monoclonal Influenza A antibody

Lung Tissue Lysate (Tumor)
1703-07 0.1 mg
EUR 336.3
Description: Lung tumor tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol.

Kidney Tissue Lysate (Tumor)
1707-07 0.1 mg
EUR 336.3
Description: Kidney tumor tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol.

Breast Tissue Lysate (Normal)
1710-07 0.1 mg
EUR 260.7
Description: Breast tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol.

Breast Tissue Lysate (Tumor)
1714-07 0.1 mg
EUR 336.3
Description: Breast tumor tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol.

Colon Tissue Lysate (Normal)
1715-07 0.1 mg
EUR 260.7
Description: Colon tissue lysate was prepared by homogenization in modified RIPA buffer (150 mM sodium chloride, 50 mM Tris-HCl, pH 7.4, 1 mM ethylenediaminetetraacetic acid, 1 mM phenylmethylsulfonyl fluoride, 1% Triton X-100, 1% sodium deoxycholic acid, 0.1% sodium dodecylsulfate, 5 μg/ml of aprotinin, 5 μg/ml of leupeptin. Tissue and cell debris was removed by centrifugation. Protein concentration was determined with Bio-Rad protein assay. The product was boiled for 5 min in 1 x SDS sample buffer (50 mM Tris-HCl pH 6.8, 12.5% glycerol, 1% sodium dodecylsulfate, 0.01% bromophenol blue) containing 5% β-mercaptoethanol.

Influenza A Hemagglutinin H1 (A/Brisbane/59/2007)(H1N1) Peptide
11-563 0.05 mg
EUR 632.4
Description: Influenza A Hemagglutinin H1 (A/Brisbane/59/2007)(H1N1) Peptide

Influenza A Hemagglutinin H1 (A/Brisbane/59/2007)(H1N1) Peptide
11-564 0.05 mg
EUR 632.4
Description: Influenza A Hemagglutinin H1 (A/Brisbane/59/2007)(H1N1) Peptide

MBD1 Polyclonal Antibody
A-1006
  • EUR 740.34
  • EUR 117.70
  • EUR 306.90
  • EUR 462.00
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

5-Methylcytosine (5-mC) Monoclonal Antibody [33D3]
A-1014
  • EUR 721.20
  • EUR 82.50
  • EUR 239.80
  • EUR 456.50
  • 100 µg
  • 10 ug
  • 50 ug
  • 100 ug

5-Hydroxymethylcytosine (5-hmC) Monoclonal Antibody [HMC/4D9]
A-1018
  • EUR 702.06
  • EUR 82.50
  • EUR 239.80
  • EUR 443.30
  • 100 µg
  • 10 ug
  • 50 ug
  • 100 ug

PRDM4 Polyclonal Antibody
A-2004
  • EUR 754.26
  • EUR 117.70
  • EUR 284.90
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

PRDM5 Polyclonal Antibody
A-2005
  • EUR 754.26
  • EUR 117.70
  • EUR 284.90
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

PRDM10 Polyclonal Antibody
A-2010
  • EUR 754.26
  • EUR 117.70
  • EUR 284.90
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

PRDM11 Polyclonal Antibody
A-2011
  • EUR 754.26
  • Ask for price
  • Ask for price
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

PRDM13 Polyclonal Antibody
A-2013
  • EUR 754.26
  • Ask for price
  • Ask for price
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

PRDM16 Polyclonal Antibody
A-2016
  • EUR 754.26
  • EUR 117.70
  • EUR 284.90
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

PRDM17 Polyclonal Antibody
A-2017
  • EUR 754.26
  • EUR 117.70
  • EUR 284.90
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

EZH1 Polyclonal Antibody
A-2018
  • EUR 754.26
  • EUR 117.70
  • EUR 284.90
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

HSF1 Polyclonal Antibody
A-2401
  • EUR 905.64
  • EUR 235.40
  • EUR 423.50
  • EUR 574.20
  • 200 µl
  • 50 ul
  • 100 ul
  • 200 ul

PRMT3 Polyclonal Antibody
A-3003
  • EUR 740.34
  • Ask for price
  • Ask for price
  • EUR 462.00
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

SET1 Polyclonal Antibody
A-3011
  • EUR 754.26
  • EUR 117.70
  • EUR 284.90
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

SET07 Polyclonal Antibody
A-3013
  • EUR 754.26
  • Ask for price
  • Ask for price
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

LSD1 Polyclonal Antibody
A-3018
  • EUR 754.26
  • EUR 117.70
  • EUR 284.90
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

HDAC10 Polyclonal Antibody
A-4010
  • EUR 754.26
  • Ask for price
  • Ask for price
  • EUR 470.80
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

PCAF Polyclonal Antibody
A-4012
  • EUR 740.34
  • EUR 117.70
  • EUR 306.90
  • EUR 462.00
  • 100 µg
  • 20 ul
  • 50 ul
  • 100 ul

Histone H3K9ac (Acetyl H3K9) Polyclonal Antibody
A-4022
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K14ac (Acetyl H3K14) Polyclonal Antibody
A-4023
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K18ac (Acetyl H3K18) Polyclonal Antibody
A-4024
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K23ac (Acetyl H3K23) Polyclonal Antibody
A-4025
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 383.90
  • 50 µg
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K56ac (Acetyl H3K56) Polyclonal Antibody
A-4026
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K4me1 (H3K4 Monomethyl) Polyclonal Antibody
A-4031
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K4me2 (H3K4 Dimethyl) Polyclonal Antibody
A-4032
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 383.90
  • 50 µg
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K4me3 (H3K4 Trimethyl) Polyclonal Antibody
A-4033
  • EUR 555.90
  • EUR 177.10
  • EUR 342.10
  • EUR 479.60
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K9me1 (H3K9 Monomethyl) Polyclonal Antibody
A-4034
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K9me2 (H3K9 Dimethyl) Polyclonal Antibody
A-4035
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K9me3 (H3K9 Trimethyl) Polyclonal Antibody
A-4036
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K27me1 (H3K27 Monomethyl) Polyclonal Antibody
A-4037
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K27me2 (H3K27 Dimethyl) Polyclonal Antibody
A-4038
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K27me3 (H3K27 Trimethyl) Polyclonal Antibody
A-4039
  • EUR 555.90
  • EUR 177.10
  • EUR 342.10
  • EUR 479.60
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K36me1 (H3K36 Monomethyl) Polyclonal Antibody
A-4040
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K36me2 (H3K36 Dimethyl) Polyclonal Antibody
A-4041
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K36me3 (H3K36 Trimethyl) Polyclonal Antibody
A-4042
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K79me1 (H3K79 Monomethyl) Polyclonal Antibody
A-4043
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K79me2 (H3K79 Dimethyl) Polyclonal Antibody
A-4044
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K79me3 (H3K79 Trimethyl) Polyclonal Antibody
A-4045
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H4K20me1 (H4K20 Monomethyl) Polyclonal Antibody
A-4046
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H4K20me2 (H4K20 Dimethyl) Polyclonal Antibody
A-4047
  • EUR 555.90
  • EUR 173.80
  • EUR 336.60
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H4K20me3 (H4K20 Trimethyl) Polyclonal Antibody
A-4048
  • EUR 555.90
  • EUR 173.80
  • EUR 302.50
  • EUR 470.80
  • 50 µl
  • 25 ul
  • 50 ul
  • 100 ul

Histone H3K27ac (Acetyl H3K27) Polyclonal Antibody
A-4708
  • EUR 813.42
  • EUR 173.80
  • EUR 299.20
  • EUR 510.40
  • 100 µl
  • 25 ul
  • 50 ul
  • 100 ul

CRISPR Cas9 Monoclonal Antibody [7A9]
A-9000
  • EUR 573.30
  • EUR 71.50
  • EUR 200.20
  • EUR 355.30
  • 100 µg
  • 10 ug
  • 50 ug
  • 100 ug

CRISPR/Cas9 (SaCas9) Monoclonal Antibody [6H4]
A-9001
  • EUR 559.38
  • EUR 70.40
  • EUR 192.50
  • EUR 338.80
  • 100 µg
  • 10 ug
  • 50 ug
  • 100 ug

Influenza A Virus H3 Antigen Antibody
abx415738-01mg 0.1 mg
EUR 861.6

Influenza A virus H3 PCR kit
PCR-H649-48R 50T
EUR 987.6

Influenza A virus H3 PCR kit
PCR-H649-96R 100T
EUR 1335.6

CLIMP-63 Polyclonal Antibody
A-0701
  • EUR 754.26
  • EUR 290.40
  • EUR 470.80
  • 100 µl
  • 50 ul
  • 100 ul

DNMT3A Polyclonal Antibody
A-1003
  • EUR 740.34
  • EUR 235.40
  • EUR 462.00
  • 100 µl
  • 50 ul
  • 100 ul

DNMT3B Polyclonal Antibody
A-1004
  • EUR 740.34
  • EUR 235.40
  • EUR 462.00
  • 100 µl
  • 50 ul
  • 100 ul

Molecular docking and dynamics simulations research of OmpATb identifies 4 potential novel pure product-derived anti-Mycobacterium tuberculosis compounds

The outer membrane protein A (OmpATb) of Mycobacterium tuberculosis is a virulence issue that neutralizes the host pH to impede the uptake of hydrophilic antitubercular medicine.
Figuring out pure compounds with the potential to inhibit OmpATb might permit circumvention of the porin-like actions of OmpATb. 4 potential leads comprising ZINC000003958185, ZINC000000157405, ZINC000000001392 and ZINC000034268676 had been obtained by digital screening of 6394 various pure merchandise.
Characterization of the binding interactions of the potential leads with OmpATb revealed 9 essential residues comprising ARG86, LEU110, LEU113, LEU114, ALA115, PHE142, SER145, VAL146, and PHE151. Molecular dynamics simulations additionally revealed very secure protein-lead complexes.
Most residues contributed decrease binding energies to the general molecular mechanics Poisson-Boltzmann floor space (MM-PBSA) binding free energies of the interactions between the molecules and OmpATb protein.
Induced Match Docking (IFD) of the compounds regenerated poses of the molecular docking utilizing AutoDock Vina. These molecules might be beginning templates for designing inhibitors to bypass the pore mediating actions of OmpATb.
Based mostly on structural similarity, ZINC000034268676 was urged as a possible scaffold for designing efflux pump inhibitors of the gate mediating actions of OmpATb and should improve the uptake of hydrophilic medicine to scale back the length time of tuberculosis therapy.
Moreover, structurally comparable compounds obtainable within the DrugBank database with a similarity threshold of 0.7 have been reported to exhibit antitubercular and anti-mycobacterial actions.
These biomolecules may be additional characterised experimentally to corroborate their antitubercular exercise. Additionally, the skeletons of the molecules may be adopted as sub-structures for the design of future anti-mycobacterial medicine.
Key phrases: Antitubercular compounds; Induced-fit docking; MM-PBSA; Molecular docking; Molecular dynamics; Mycobacterium tuberculosis OmpATb; Pure merchandise; Digital screening.

Probing the Molecular-Stage Interactions in an Energetic Pharmaceutical Ingredient (API) – Polymer Dispersion and the Ensuing Affect on Drug Product Formulation.

An investigation of underlying mechanisms of API-polymer interplay patterns has the potential to offer helpful insights for choosing applicable formulations with superior bodily stability and processability.
On this examine, copovidone was used as a polymeric provider for a number of mannequin compounds together with clotrimazole, nifedipine, and posaconazole.
The various chemical constructions conferred the power for the mannequin compounds to type distinct interactions with copovidone. Rheology and nuclear magnetic resonance (NMR) had been mixed to research the molecular sample and relative power of energetic pharmaceutical ingredient (API)-polymer interactions.
As well as, the affect of the interactions on formulation processability by way of sizzling soften extrusion (HME) and bodily stability had been evaluated.The rheological response of an API-polymer system was discovered to be extremely delicate to API-polymer interplay, relying each on API chemistry and API-polymer miscibility.
Within the techniques studied, dispersed API induced a stronger plasticizer impact on the polymer matrix in comparison with crystalline/aggregated API.
Correspondingly, the processing torque by way of HME confirmed a proportional relationship with the utmost advanced viscosity of the API-polymer system. To be able to quantitatively consider the relative power of the API-polymer interplay, homogeneously dispersed API-polymer amorphous samples had been ready by HME at an elevated temperature. DSC, XRD, and rheology had been employed to verify the amorphous integrity and homogeneity of the resultant extrudates.
Subsequently, the homogeneously dispersed API-polymer amorphous dispersions had been interrogated by rheology and NMR to offer a qualitative and quantitative evaluation of the character of the API-polymer interplay, each macroscopically and microscopically.
Rheological grasp curves of frequency sweeps of the extrudates exhibited a powerful dependence on the API chemistry and revealed a rank ordering of the relative power of API-copovidone interactions, within the order of posaconazole > nifedipine > clotrimazole.
NMR knowledge offered the means to exactly map the API-polymer interplay sample and determine the particular websites of interplay from a molecular perspective. Lastly, the affect of API-polymer interactions on the bodily stability of the resultant extrudates was studied.
Qualitative and quantitative analysis of the relative power of the API-polymer interplay was efficiently achieved by using mixed rheology and NMR. Graphical Summary.

HRP-Goat Anti-Mouse Secondary Antibody
A12003
  • EUR 232.26
  • EUR 117.70
  • 350 µg
  • 350 ug

HRP-Goat Anti-Rabbit Secondary Antibody
A12004
  • EUR 232.26
  • EUR 117.70
  • 350 µg
  • 350 ug

Goat Anti-Rabbit Secondary Antibody, Biotin Conjugated
A12001
  • EUR 232.26
  • EUR 117.70
  • 350 µg
  • 350 ug

Goat Anti-Rat Secondary Antibody, Biotin Conjugated
A12002
  • EUR 232.26
  • EUR 117.70
  • 350 µg
  • 350 ug

Anti-Galectin 1 Antibody
A00470-2 100ug/vial
EUR 352.8

Anti-Galectin-1 antibody
PAab03314 100 ug
EUR 426

anti- Galectin-1 antibody
FNab03314 100µg
EUR 606.3
Description: Antibody raised against Galectin-1

anti- Galectin-1 antibody
FNab03315 100µg
EUR 658.5
Description: Antibody raised against Galectin-1

Anti-Galectin-1 antibody
STJ93201 200 µl
EUR 236.4
Description: Rabbit polyclonal to Galectin-1.

Anti-Galectin-1 antibody
STJ98716 200 µl
EUR 236.4
Description: Rabbit polyclonal to Galectin-1.

Anti-Galectin 1 (1A8)
YF-MA13984 100 ug
EUR 435.6
Description: Mouse monoclonal to Galectin 1

Human Galectin-1 (LGALS1)
1-CSB-EP012882HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Galectin-1(LGALS1) expressed in E.coli

Human Galectin-1 (LGALS1)
1-CSB-EP012882HUb1
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Galectin-1(LGALS1) expressed in E.coli

Human Genomic DNA 
X11000
  • Ask for price
  • EUR 235.40
  • 0.2 ml
  • 0.2 ml

Anti-Galectin 1/Lgals1 Antibody
A00470 100ug/vial
EUR 400.8

Anti-Galectin 1 Biotinylated Antibody
A00470-Biotin 50ug/vial
EUR 352.8

anti-Galectin 1 (1E8-1B2)
LF-MA10174 100 ug
EUR 435.6
Description: Mouse monoclonal to Galectin 1

Anti-Galectin 1/LGALS1 Antibody
PA1422 100ug/vial
EUR 400.8

Anti-Galectin 1/LGALS1 Antibody
PB9240 100ug/vial
EUR 400.8

Anti-galectin-1 (mouse) antibody
STJ72519 100 µg
EUR 430.8

Anti-Galectin-13 (GAL13) / Placental Protein 13 (PP13) Monoclonal Antibody
M08143-1 100ug/vial
EUR 476.4
Description: Mouse Monoclonal Galectin-13 (GAL13) / Placental Protein 13 (PP13) Antibody. Validated in IHC and tested in Human.

Human Brain Genomic DNA  
X11001
  • Ask for price
  • EUR 77.00
  • 10 µg
  • 10 ul

LGALS8 Human, Galectin-8 Human Recombinant Protein, His Tag
PROTO00214-1 Regular: 10ug
EUR 380.4
Description: LGALS8 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 337 amino acids (1-317 a.a.) and having a molecular mass of 37.9 kDa. The LGALS8 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

LGALS3 Human, Galectin-3 Human Recombinant Protein, His Tag
PROTP17931-1 Regular: 25ug
EUR 380.4
Description: LGALS3 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 270 amino acids (1-250 a.a.) and having a molecular mass of 28.3 kDa._x000D_ The LGALS3 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. _x000D_

LGALS7 Human, Galectin-7 Human Recombinant Protein, His Tag
PROTP47929-1 Regular: 20ug
EUR 380.4
Description: Galectin-7 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 156 amino acids (1-136 a.a.) and having a molecular mass of 17.2kDa. ;The Galectin-7 is purified by proprietary chromatographic techniques.

Polyclonal Goat anti-GST μ-form
GST-ANTI-2 50 uL
EUR 336

Polyclonal Goat anti-GST p-form
GST-ANTI-3 50 uL
EUR 336

Human Galectin-3 (Gal-3) AssayMax ELISA Kit
EG3311-1 96 Well Plate
EUR 572.4

Human Galectin-4 (Gal-4) AssayMax ELISA Kit
EG3312-1 96 Well Plate
EUR 572.4

anti-Galectin 3
YF-PA24079 50 ul
EUR 400.8
Description: Mouse polyclonal to Galectin 3

anti-galectin 9
YF-PA24081 50 ul
EUR 400.8
Description: Mouse polyclonal to galectin 9

anti-Galectin 3
YF-PA12946 50 ug
EUR 435.6
Description: Mouse polyclonal to Galectin 3

anti-Galectin 3
YF-PA12947 100 ul
EUR 483.6
Description: Rabbit polyclonal to Galectin 3

anti-Galectin 3
YF-PA12948 100 ug
EUR 483.6
Description: Rabbit polyclonal to Galectin 3

anti-Galectin 8
YF-PA12951 50 ul
EUR 435.6
Description: Mouse polyclonal to Galectin 8

anti-Galectin 13
YF-PA18585 50 ug
EUR 435.6
Description: Mouse polyclonal to Galectin 13

Human Galectin-1(LGALS1) ELISA kit
1-CSB-EL012882HU
  • EUR 964.80
  • EUR 6118.80
  • EUR 3244.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Galectin-1(LGALS1) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Recombinant Human Galectin-1
7-00427 10µg Ask for price

Recombinant Human Galectin-1
7-00428 50µg Ask for price

Recombinant Human Galectin-1
7-00429 1mg Ask for price

Galectin-1, human recombinant
4648-10
EUR 170.4

Galectin-1, human recombinant
4648-1000
EUR 1977.6

Galectin-1, human recombinant
4648-50
EUR 314.4

Human Galectin 1 Protein
20-abx066725
  • EUR 744.00
  • EUR 326.40
  • EUR 2230.80
  • EUR 878.40
  • EUR 543.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Anti-human Galectin-3 antibody
STJ15100163 250 µg
EUR 403.2
Description: This monoclonal antibody is for studies of antigen expression in cells and tissue sections using immunocytochemistry and immunoprecipitation

Bovine Galectin-1 (LGALS1)
1-CSB-EP012882BO
  • EUR 733.20
  • EUR 370.80
  • EUR 2192.40
  • EUR 1126.80
  • EUR 1461.60
  • EUR 476.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Bovine Galectin-1(LGALS1) expressed in E.coli

SARS-CoV-2 Spike S1 RBD Protein, Human Fc-Fusion, Avi-Tag
E80025
  • EUR 635.80
  • EUR 3934.70
  • 100 ul
  • 1 ml

Anti-Galectin-9 Antibody
A03415 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for Galectin-9 Antibody (LGALS9) detection.tested for WB in Human, Mouse, Rat.

Anti-Galectin 2 antibody
PAab03310 100 ug
EUR 494.4

Anti-Galectin 4 antibody
PAab03311 100 ug
EUR 426

Anti-Galectin 8 antibody
PAab03312 100 ug
EUR 426

Anti-Galectin 9 antibody
PAab03313 100 ug
EUR 426

Anti-Galectin-3 antibody
PAab03316 100 ug
EUR 426

Anti-Galectin-7 antibody
PAab03318 100 ug
EUR 426

anti-Galectin-3 (6G2)
LF-MA20336 100 ug
EUR 424.8
Description: Mouse monoclonal to Galectin-3

anti- Galectin 2 antibody
FNab03310 100µg
EUR 702
Description: Antibody raised against Galectin 2

anti- Galectin 4 antibody
FNab03311 100µg
EUR 606.3
Description: Antibody raised against Galectin 4

anti- Galectin 8 antibody
FNab03312 100µg
EUR 606.3
Description: Antibody raised against Galectin 8

anti- Galectin 9 antibody
FNab03313 100µg
EUR 606.3
Description: Antibody raised against Galectin 9

anti- Galectin-3 antibody
FNab03316 100µg
EUR 606.3
Description: Antibody raised against Galectin-3

anti- Galectin-3 antibody
FNab03317 100µg
EUR 658.5
Description: Antibody raised against Galectin-3

anti- Galectin-7 antibody
FNab03318 100µg
EUR 606.3
Description: Antibody raised against Galectin-7

Anti-Galectin-2 antibody
STJ93202 200 µl
EUR 236.4
Description: Rabbit polyclonal to Galectin-2.

Anti-Galectin-4 antibody
STJ93203 200 µl
EUR 236.4
Description: Rabbit polyclonal to Galectin-4.

Anti-Galectin-7 antibody
STJ93204 200 µl
EUR 236.4
Description: Rabbit polyclonal to Galectin-7.

Anti-Galectin-8 antibody
STJ93205 200 µl
EUR 236.4
Description: Rabbit polyclonal to Galectin-8.

Anti-Galectin-9 antibody
STJ93206 200 µl
EUR 236.4
Description: Rabbit polyclonal to Galectin-9.

Anti-Galectin-3 antibody
STJ96945 200 µl
EUR 236.4
Description: Galectin-3 is a protein encoded by the LGALS3 gene which is approximately 26,1 kDa. Galectin-3 is localised to the cytoplasm and nucleus. It is involved in NF-kappaB signalling, advanced glycosylation end product receptor signalling and cell adhesion. It is a galactose-specific lectin which binds IgE and may mediate the stimulation by CSPG4 of endothelial cells migration along with the alpha-3, beta-1 integrin. It is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. Galectin-3 is expressed mainly in the colonic epithelium and is also abundantly expressed in activated macrophages. Mutations in the LGALS3 gene may result in follicular adenoma and thyroid cancer. STJ96945 was developed from clone 6G2 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This antibody detects endogenous galectin-3 proteins.

Anti-Galectin-3 antibody
STJ97549 200 µl
EUR 236.4
Description: Mouse monoclonal to Galectin-3 (6B8).

Anti-Galectin-3 antibody
STJ97550 200 µl
EUR 236.4
Description: Mouse monoclonal to Galectin-3 (8D7).

Anti-Galectin-3 antibody
STJ97551 200 µl
EUR 236.4
Description: Mouse monoclonal to Galectin-3 (5D9).

Anti-Galectin-3 antibody
STJ97601 200 µl
EUR 236.4
Description: Mouse monoclonal to Galectin-3 (2F9).

Anti-Galectin-3 antibody
STJ97604 200 µl
EUR 236.4
Description: Mouse monoclonal to Galectin-3 (16E6).

Anti-Galectin-3 antibody
STJ97605 200 µl
EUR 236.4
Description: Mouse monoclonal to Galectin-3 (1H4).

Anti-Galectin-3 antibody
STJ97715 200 µl
EUR 236.4
Description: Mouse monoclonal to Galectin-3.

Anti-Galectin-3 antibody
STJ16100369 1 mL
EUR 1256.4

Anti-Galectin-3 antibody
STJ16100782 100 µg
EUR 864

Anti-Galectin-3 antibody
STJ180106 0.1 ml
EUR 254.4

Anti-Galectin 3 antibody
STJ190057 200 µl
EUR 236.4
Description: Unconjugated Mouse monoclonal to Galectin 3 (AS1A24)

Anti-Galectin 3 antibody
STJ73098 100 µg
EUR 430.8

Anti-Galectin 8 (3E5)
YF-MA13986 100 ug
EUR 435.6
Description: Mouse monoclonal to Galectin 8

Galectin 1 antibody
70R-11939 100 ug
EUR 483.6
Description: Rabbit polyclonal Galectin 1 antibody

Galectin 1 antibody
70R-49997 100 ul
EUR 292.8
Description: Purified Polyclonal Galectin 1 antibody

Galectin 1 antibody
70R-13963 100 ug
EUR 386.4
Description: Affinity purified Rabbit polyclonal Galectin 1 antibody

Galectin 1 protein
30R-1385 100 ug
EUR 268.8
Description: Purified recombinant Human Galectin 1 protein

Galectin 1 protein
30R-2371 50 ug
EUR 423.6
Description: Purified recombinant Human Galectin 1 protein

Galectin 1 Antibody
49673-100ul 100ul
EUR 399.6

Galectin 1 Antibody
49673-50ul 50ul
EUR 286.8

Galectin-1 Antibody
3596-100
EUR 379.2

Omar

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February 2023
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